Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7630
Title: Organ-On-A-Chip Devices: Technology Progress and Challenges
Authors: Obeid, Pierre J. 
Yammine, Paolo 
Nakat, Hanna El 
Kassab, Rima 
Tannous, Tony 
Nasr, Zeina 
Maarawi, Therese 
Dahdah, Norma
El Safadi, Ali
Mansour, Agapy
Chmayssem, Ayman
Affiliations: Department of Chemistry 
Department of Chemistry 
Department of Chemistry 
Department of Chemistry 
Department of Physics 
Department of Biology 
Department of Medical Laboratory Sciences 
Keywords: Biomaterials
Human-on-a-chip
Microfluidic devices
Organ-on-a-chip
Sensors and biosensors
Issue Date: 2024-08-25
Publisher: Wiley
Part of: ChemBioChem
Abstract: 
Organ-On-a-Chip (OOC) is a multichannel 3D-microfluidic cell-culture system incorporated in a chip that simulates the behavior of an organ. This technology relies on a multidisciplinary science that benefits from and contributes in the progress of many fields including microbiology, microfluidics, biomaterials, and bioengineering. This review article summarizes the progress and achievements of various organ-on-chip technologies. It highlights the significant advantages of this technology in terms of reducing animal testing and providing personalized medical responses. In addition, this paper demonstrates how OOC is becoming a promising and powerful tool in pharmaceutical research to combat diseases. It predicts not only the effects of drugs on the target organs but also, using body-on-a-chip systems, it may provide insights into the side effects of the drug delivery on the other organs. Likewise, the models used for the construction of various organ-on-a-chip devices are investigated along with the design and materials of microfluidic devices. For each OOC, the integrated monitoring devices within the chips (e. g., sensors and biosensors) are discussed. We also discuss the evolution of FDA regulations and the potential in the near future for integrating OOCs into protocols that support and reduce the need for and the failure rates in preclinical and clinical studies.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7630
ISSN: 14394227
DOI: 10.1002/cbic.202400580
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology
Department of Chemistry
Department of Physics
Department of Medical Laboratory Sciences

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