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|Title:||The Antioxidant and Anti-proliferative Activity of the Lebanese Olea europaea Extract||Authors:||Fares, Rida
Baydoun, Serine E.
|Affiliations:||Department of Biology
Department of Biology
|Subjects:||Antioxidants||Issue Date:||2011||Part of:||Plant foods for human nutrition||Volume:||66||Issue:||1||Start page:||58||End page:||63||Abstract:||
It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties. In this study, the anti-proliferative activity of plant extracts from olive (Olea europaea L.) leaves was tested on human leukemic cell line (Jurkat). Cytotoxicity of various concentrations of plant extracts was examined and the IC50 was determined. Olive leaf extracts showed concentration-dependent anti-proliferative effect as determined by the WST-1 proliferation kit and [3H]-thymidine incorporation method. To study whether cell death was due to apoptosis, cells were stained with Annexin V-FITC and PI and the expression of important regulatory proteins (Bcl-2, Bax, and p53) involved in apoptosis were examined by Western blot. The antioxidant activity of olive leaves (SC50 = 0.1 mg dry weight) was studied using the DPPH scavenging method. Present findings suggest that olive leaves extracts exhibit anti-proliferative effect on leukemic cells by inducing apoptosis.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/1629||Ezproxy URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Biology|
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