Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/1629
Title: The antioxidant and anti-proliferative activity of the lebanese olea europaea extract
Authors: Fares, Rida
Bazzi, Samer 
Baydoun, Serine E.
Abdel-Massih, Roula
Affiliations: Department of Biology 
Department of Biology 
Keywords: Anti-proliferative
Apoptosis
DPPH
Jurkat
Olea europaea
Subjects: Antioxidants
Issue Date: 2011
Part of: Plant foods for human nutrition
Volume: 66
Issue: 1
Start page: 58
End page: 63
Abstract: 
It is becoming increasingly evident that certain phytochemicals possess cancer chemopreventive properties. In this study, the anti-proliferative activity of plant extracts from olive (Olea europaea L.) leaves was tested on human leukemic cell line (Jurkat). Cytotoxicity of various concentrations of plant extracts was examined and the IC50 was determined. Olive leaf extracts showed concentration-dependent anti-proliferative effect as determined by the WST-1 proliferation kit and [3H]-thymidine incorporation method. To study whether cell death was due to apoptosis, cells were stained with Annexin V-FITC and PI and the expression of important regulatory proteins (Bcl-2, Bax, and p53) involved in apoptosis were examined by Western blot. The antioxidant activity of olive leaves (SC50 = 0.1 mg dry weight) was studied using the DPPH scavenging method. Present findings suggest that olive leaves extracts exhibit anti-proliferative effect on leukemic cells by inducing apoptosis.
URI: https://scholarhub.balamand.edu.lb/handle/uob/1629
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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