Please use this identifier to cite or link to this item:
|Title:||Degradomics in Neurotrauma : Profiling Traumatic Brain Injury||Authors:||Abou El Hassan, Hadi
Assaf, Edwyn Jeremy
Kobeissy, Firas H.
|Affiliations:||Department of Biology||Keywords:||Degradomics
|Issue Date:||2017||Part of:||J. Walker, J. Pollard & E. Murray (Eds.), Methods in Molecular Biology. Humana Press.||Start page:||65||End page:||99||Abstract:||
Degradomics has recently emerged as a subdiscipline in the omics era with a focus on characterizing signature breakdown products implicated in various disease processes. Driven by promising experimental findings in cancer, neuroscience, and metabolomic disorders, degradomics has significantly promoted the notion of disease-specific "degradome." A degradome arises from the activation of several proteases that target specific substrates and generate signature protein fragments. Several proteases such as calpains, caspases, cathepsins, and matrix metalloproteinases (MMPs) are involved in the pathogenesis of numerous diseases that disturb the physiologic balance between protein synthesis and protein degradation. While regulated proteolytic activities are needed for development, growth, and regeneration, uncontrolled proteolysis initiated under pathological conditions ultimately culminates into apoptotic and necrotic processes. In this chapter, we aim to review the protease-substrate repertoires in neural injury concentrating on traumatic brain injury. A striking diversity of protease substrates, essential for neuronal and brain structural and functional integrity, namely, encryptic biomarker neoproteins, have been characterized in brain injury. These include cytoskeletal proteins, transcription factors, cell cycle regulatory proteins, synaptic proteins, and cell junction proteins. As these substrates are subject to proteolytic fragmentation, they are ceaselessly exposed to activated proteases. Characterization of these molecules allows for a surge of "possible" therapeutic approaches of intervention at various levels of the proteolytic cascade.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/81||Ezproxy URL:||Link to full text||Type:||Book Chapter|
|Appears in Collections:||Department of Biology|
Show full item record
checked on Jun 23, 2021
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.