Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/81
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dc.contributor.authorAbou El Hassan, Hadien_US
dc.contributor.authorSukhon, Faresen_US
dc.contributor.authorAssaf, Edwyn Jeremyen_US
dc.contributor.authorBahmad, Hishamen_US
dc.contributor.authorAbou-Abbass, Husseinen_US
dc.contributor.authorJourdi, Hussamen_US
dc.contributor.authorKobeissy, Firas H.en_US
dc.date.accessioned2020-12-23T08:25:20Z-
dc.date.available2020-12-23T08:25:20Z-
dc.date.issued2017-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/81-
dc.description.abstractDegradomics has recently emerged as a subdiscipline in the omics era with a focus on characterizing signature breakdown products implicated in various disease processes. Driven by promising experimental findings in cancer, neuroscience, and metabolomic disorders, degradomics has significantly promoted the notion of disease-specific "degradome." A degradome arises from the activation of several proteases that target specific substrates and generate signature protein fragments. Several proteases such as calpains, caspases, cathepsins, and matrix metalloproteinases (MMPs) are involved in the pathogenesis of numerous diseases that disturb the physiologic balance between protein synthesis and protein degradation. While regulated proteolytic activities are needed for development, growth, and regeneration, uncontrolled proteolysis initiated under pathological conditions ultimately culminates into apoptotic and necrotic processes. In this chapter, we aim to review the protease-substrate repertoires in neural injury concentrating on traumatic brain injury. A striking diversity of protease substrates, essential for neuronal and brain structural and functional integrity, namely, encryptic biomarker neoproteins, have been characterized in brain injury. These include cytoskeletal proteins, transcription factors, cell cycle regulatory proteins, synaptic proteins, and cell junction proteins. As these substrates are subject to proteolytic fragmentation, they are ceaselessly exposed to activated proteases. Characterization of these molecules allows for a surge of "possible" therapeutic approaches of intervention at various levels of the proteolytic cascade.en_US
dc.format.extent34 p.en_US
dc.language.isoengen_US
dc.subjectDegradomicsen_US
dc.subjectDegradomeen_US
dc.subjectDegradation (C)en_US
dc.subjectProteolysisen_US
dc.subjectBreakdownen_US
dc.subjectBiomarkeren_US
dc.subjectProteaseen_US
dc.subjectCalpainen_US
dc.subjectCaspaseen_US
dc.subjectTraumaen_US
dc.subjectInjuryen_US
dc.subject.lcshBig dataen_US
dc.subject.lcshBrainen_US
dc.titleDegradomics in Neurotrauma : Profiling Traumatic Brain Injuryen_US
dc.typeBook Chapteren_US
dc.contributor.affiliationDepartment of Biologyen_US
dc.description.startpage65en_US
dc.description.endpage99en_US
dc.date.catalogued2019-05-03-
dc.description.statusPublisheden_US
dc.identifier.ezproxyURLhttp://ezsecureaccess.balamand.edu.lb/login?url=https://link.springer.com/protocol/10.1007%2F978-1-4939-6952-4_4en_US
dc.identifier.OlibID191593-
dc.relation.ispartoftextJ. Walker, J. Pollard & E. Murray (Eds.), Methods in Molecular Biology. Humana Press.en_US
dc.provenance.recordsourceOliben_US
Appears in Collections:Department of Biology
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