Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7535
Title: A Potential Link between Myeloperoxidase Modified LDL, Atherosclerosis and Depression
Authors: Daher, Jalil 
Affiliations: Department of Biology 
Keywords: BDNF
CD
MDD
Mox-LDL
atherosclerosis
depression
neuroserpin
tPA
Issue Date: 2024-08-13
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
Part of: International Journal of Molecular Sciences
Volume: 25
Issue: 16
Abstract: 
Atherosclerosis is a chronic inflammatory disease that involves modified low-density lipoproteins (LDL) which play a pivotal role in the initiation and progression of the disease. Myeloperoxidase oxidized LDL (Mox-LDL) is considered to be the most patho-physiologically relevant type of modified LDL and has been reported to be ubiquitously present in atheroma plaques of patients with atherosclerosis. Besides its involvement in the latter disease state, Mox-LDL has also been shown to be implicated in the pathogenesis of various illnesses including sleep disorders, which are in turn associated with heart disease and depression in many intricate ways. Meanwhile, we have recently shown that lox-1-mediated Mox-LDL signaling modulates neuroserpin activity in endothelial cells, which could have major implications that go beyond the pathophysiology of stroke and cerebrovascular disease (CD). Of note is that tissue plasminogen activator (tPA), which is the main target of neuroserpin in the brain, has a crucial function in the processing of brain-derived neurotrophic factor (BDNF) into its mature form. This factor is known to be involved in major depressive disorder (MDD) development and pathogenesis. Since tPA is more conventionally recognized as being involved in fibrinolytic mechanisms, and its effect on the BDNF system in the context of MDD is still not extensively studied, we speculate that any Mox-LDL-driven change in the activity of tPA in patients with atherosclerosis may lead to a decrease in the production of mature BDNF, resulting in impaired neural plasticity and depression. Deciphering the mechanisms of interaction between those factors could help in better understanding the potentially overlapping pathological mechanisms that regulate disease processes in CD and MDD, supporting the possibility of novel and common therapeutic opportunities for millions of patients worldwide.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7535
ISSN: 16616596
DOI: 10.3390/ijms25168805
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

Show full item record

Record view(s)

16
checked on Dec 14, 2024

Google ScholarTM

Check

Altmetric

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.