Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5282
Title: Antibacterial activity of two endemic Lebanese medicinal plants, Origanum libanoticum and Berberis libanotica, on human pathogenic bacteria
Authors: Darwich, Lynn
El-Sawalhi, Sabah
Hamzeh, Omar M.
Beyrouthy, Marc El
Iriti, Marcello
Abdel-Massih, Roula M.
Affiliations: Faculty of Medicine 
Department of Biology 
Keywords: Antibacterial activity
Berberis libanotica
DPPH scavenging activity
Minimum inhibitory concentration
Origanum libanoticum
Issue Date: 2021
Part of: Plant Biosystems
Abstract: 
The alarming spread of antimicrobial resistance has enticed researchers to search for new effective antimicrobial compounds from natural products. In this study, two plants endemic to Lebanon, Origanum libanoticum and Berberis libanotica, were selected due to their numerous uses in traditional medicine. Methanolic extracts were prepared from plant aerial parts and the chemical composition was analyzed by Gas Chromatography and Mass Spectrometry (GC–MS). Origanum libanoticum exhibited a strong antibacterial activity against Staphylococcus aureus (Minimum Inhibitory Concentration (MIC) 1.56–12.5 mg/mL), Escherichia coli (MIC 1.56–25 mg/mL), Pseudomonas strains (MIC 6.25–25 mg/mL), Klebsiella strains (MIC 3.12–25 mg/mL) and the lowest antibacterial activity was against Acinetobacter strains (MIC between 3.12 and 50 mg/mL). Similarly, B. libanotica showed a strong antimicrobial activity against Staphylococcus strains (MIC 1.56-6.25 mg/mL), E. coli (MIC 0.78-6.25 mg/mL), Klebsiella strains (MIC 0.78-6.25 mg/mL) and Pseudomonas strains (MIC 1.56–12.5 mg/mL). The methanolic extracts showed strong scavenging activity at 0.5 mg.mL−1. Berberis libanotica was further fractionated with solvents of different polarity. MICs ranged between 0.47 and 7.5 mg/mL for different fractions tested. Both extracts exhibit a promising antibacterial activity. More work is needed to identify the active compound(s).
URI: https://scholarhub.balamand.edu.lb/handle/uob/5282
ISSN: 11263504
DOI: 10.1080/11263504.2021.2013332
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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