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dc.contributor.authorDarwich, Lynnen_US
dc.contributor.authorEl-Sawalhi, Sabahen_US
dc.contributor.authorHamzeh, Omar M.en_US
dc.contributor.authorBeyrouthy, Marc Elen_US
dc.contributor.authorIriti, Marcelloen_US
dc.contributor.authorAbdel-Massih, Roula M.en_US
dc.description.abstractThe alarming spread of antimicrobial resistance has enticed researchers to search for new effective antimicrobial compounds from natural products. In this study, two plants endemic to Lebanon, Origanum libanoticum and Berberis libanotica, were selected due to their numerous uses in traditional medicine. Methanolic extracts were prepared from plant aerial parts and the chemical composition was analyzed by Gas Chromatography and Mass Spectrometry (GC–MS). Origanum libanoticum exhibited a strong antibacterial activity against Staphylococcus aureus (Minimum Inhibitory Concentration (MIC) 1.56–12.5 mg/mL), Escherichia coli (MIC 1.56–25 mg/mL), Pseudomonas strains (MIC 6.25–25 mg/mL), Klebsiella strains (MIC 3.12–25 mg/mL) and the lowest antibacterial activity was against Acinetobacter strains (MIC between 3.12 and 50 mg/mL). Similarly, B. libanotica showed a strong antimicrobial activity against Staphylococcus strains (MIC 1.56-6.25 mg/mL), E. coli (MIC 0.78-6.25 mg/mL), Klebsiella strains (MIC 0.78-6.25 mg/mL) and Pseudomonas strains (MIC 1.56–12.5 mg/mL). The methanolic extracts showed strong scavenging activity at 0.5 mg.mL−1. Berberis libanotica was further fractionated with solvents of different polarity. MICs ranged between 0.47 and 7.5 mg/mL for different fractions tested. Both extracts exhibit a promising antibacterial activity. More work is needed to identify the active compound(s).en_US
dc.publisherTaylor & Francis Onlineen_US
dc.subjectAntibacterial activityen_US
dc.subjectBerberis libanoticaen_US
dc.subjectDPPH scavenging activityen_US
dc.subjectMinimum inhibitory concentrationen_US
dc.subjectOriganum libanoticumen_US
dc.titleAntibacterial activity of two endemic Lebanese medicinal plants, Origanum libanoticum and Berberis libanotica, on human pathogenic bacteriaen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.contributor.affiliationDepartment of Biologyen_US
dc.relation.ispartoftextPlant Biosystemsen_US
Appears in Collections:Faculty of Medicine
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