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Title: ApolipoproteinL1 is expressed in papillary thyroid carcinomas
Authors: Chidiac, Mounia
Fayyad-Kazan, Mohammad
Daher, Jalil 
Poelvoorde, Philippe
Bar, Isabelle
Maenhaut, Carine
Delrée, Paul
Badran, Bassam
Vanhamme, Luc
Affiliations: Department of Biology 
Keywords: Apolipoprotein L1
Papillary thyroid carcinoma
Issue Date: 2016
Publisher: Elsevier
Part of: Pathology - Research and Practice
Volume: 212
Issue: 7
Start page: 631
End page: 635
The apolipoprotein L (apoL) family has not yet been ascribed any definite patho-physiological function although the conserved BH3 protein domain suggests a role in programmed cell death. As repression of the regular apoptotic program is considered a hallmark of tumor progression, we investigated apoL expression in cancer. We show that the levels of one member of the family, apolipoprotein L1 (apoL1) is higher in papillary thyroid carcinoma compared to normal tissue. A combination of qRTPCR, immunohistochemistry and in situ hybridization allowed us to ascribe this increase to endogenous overexpression in carcinoma cells. Whether apoL1 plays an instrumental role in refraining cell death is the subject of ongoing molecular biology experiments.
ISSN: 03440338
DOI: 10.1016/j.prp.2016.04.004
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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