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|Title:||The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line||Authors:||Abdel-Massih, Roula
Baydoun, Elias A-H.
|Affiliations:||Department of Biology
Department of Biology
|Subjects:||Antioxidants||Issue Date:||2010||Part of:||Leukemia research||Volume:||34||Issue:||8||Start page:||1052||End page:||1056||Abstract:||
Scientists are constantly searching for phytochemicals and compounds with anti-cancer and antioxidant activity. In this study, the anti-proliferative activity of plant extracts from Origanum majorana (marjoram) was tested on human lymphoblastic leukemia cell line Jurkat. Cytotoxicity was examined using non-radioactive cytotoxicity assay and the IC50 was calculated. At non-cytotoxic concentrations, the viability of cells decreased with increase of concentration of plant extract. The anti-proliferative effect was also found to be dose-dependent. Analysis via flow cytometry shows that marjoram extracts stimulated apoptosis. Induction of apoptosis was caused by an up-regulation of p53 protein levels and down-regulation of Bcl-2α. Marjoram exhibited a strong scavenging activity (SC50 = 0.03 mg dry weight). The conclusions from this study suggest that marjoram extracts exhibit anti-proliferative effect and high antioxidant activity. For that it merits further investigation as a potential therapeutic agent.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/1633||DOI:||10.1016/j.leukres.2009.09.018||Ezproxy URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Biology|
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