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Title: The apoptotic and anti-proliferative activity of Origanum majorana extracts on human leukemic cell line
Authors: Abdel-Massih, Roula
Fares, Rida
Bazzi, Samer 
El-Chami, Nisrine
Baydoun, Elias A-H.
Affiliations: Department of Biology 
Department of Biology 
Keywords: Origanum majorana
Subjects: Antioxidants
Issue Date: 2010
Part of: Leukemia research
Volume: 34
Issue: 8
Start page: 1052
End page: 1056
Scientists are constantly searching for phytochemicals and compounds with anti-cancer and antioxidant activity. In this study, the anti-proliferative activity of plant extracts from Origanum majorana (marjoram) was tested on human lymphoblastic leukemia cell line Jurkat. Cytotoxicity was examined using non-radioactive cytotoxicity assay and the IC50 was calculated. At non-cytotoxic concentrations, the viability of cells decreased with increase of concentration of plant extract. The anti-proliferative effect was also found to be dose-dependent. Analysis via flow cytometry shows that marjoram extracts stimulated apoptosis. Induction of apoptosis was caused by an up-regulation of p53 protein levels and down-regulation of Bcl-2α. Marjoram exhibited a strong scavenging activity (SC50 = 0.03 mg dry weight). The conclusions from this study suggest that marjoram extracts exhibit anti-proliferative effect and high antioxidant activity. For that it merits further investigation as a potential therapeutic agent.
DOI: 10.1016/j.leukres.2009.09.018
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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