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Title: | A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells | Authors: | Wehbe, Terek W Abi Chahine, Nassim H Annous, Abdul-Rahman A Ferri, Mohammad A Boulous, Robert C El-Mestrah, Majid F |
Affiliations: | Faculty of Health Sciences | Keywords: | Mononuclear stem cells Bone marrow cells Liver cirrhosis |
Issue Date: | 2017 | Publisher: | National Library of Medicine | Part of: | Stem Cell Investigation | Volume: | 4 | Issue: | 9 | Abstract: | Liver cirrhosis represents a state of end-stage failure that is usually fatal. The condition results in liver dysfunction, recurrent ascites, encephalopathy, renal failure, splenomegaly, bleeding, and a poor quality of life in general. With the current severe shortage of donated organs, the only available treatment in the developing countries remains palliative care. We report a case of congenital metabolic liver cirrhosis due to glycogen storage disease diagnosed at age eight. The patient, a male, received bone marrow derived mononuclear cells (BMMC) at age 16 and again at age 17 with significant improvement of his biochemical liver function tests, ascites build-up, asthenia, splenomegaly and quality of life. Furthermore, liver biopsies showed clear reduction of the inflammation and fibrosis from Ishak score dropped from 3 to 1 paralleling the symptomatic improvement of the patient. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/5891 | ISSN: | 2306-9759 | DOI: | 10.21037/sci.2017.07.04 | Open URL: | Link to full text | Type: | Journal Article |
Appears in Collections: | Department of Medical Laboratory Sciences |
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