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Title: A case report of congenital glycogen storage liver cirrhosis treated with bone marrow derived stem cells
Authors: Wehbe, Terek W
Abi Chahine, Nassim H
Annous, Abdul-Rahman A
Ferri, Mohammad A
Boulous, Robert C
El-Mestrah, Majid F
Affiliations: Faculty of Health Sciences 
Keywords: Mononuclear stem cells
Bone marrow cells
Liver cirrhosis
Issue Date: 2017
Publisher: National Library of Medicine
Part of: Stem Cell Investigation
Volume: 4
Issue: 9
Liver cirrhosis represents a state of end-stage failure that is usually fatal. The condition results in liver dysfunction, recurrent ascites, encephalopathy, renal failure, splenomegaly, bleeding, and a poor quality of life in general. With the current severe shortage of donated organs, the only available treatment in the developing countries remains palliative care. We report a case of congenital metabolic liver cirrhosis due to glycogen storage disease diagnosed at age eight. The patient, a male, received bone marrow derived mononuclear cells (BMMC) at age 16 and again at age 17 with significant improvement of his biochemical liver function tests, ascites build-up, asthenia, splenomegaly and quality of life. Furthermore, liver biopsies showed clear reduction of the inflammation and fibrosis from Ishak score dropped from 3 to 1 paralleling the symptomatic improvement of the patient.
ISSN: 2306-9759
DOI: 10.21037/sci.2017.07.04
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Medical Laboratory Sciences

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