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Title: Exogenous IL-13 exacerbates Leishmania major infection and abrogates acquired immunity to re-infection
Authors: Zaatar, Muriel T
Simaan, Youssef
Karam, Marc C
Affiliations: Faculty of Arts and Sciences 
Keywords: Interleukin-13
T helper polarization
Issue Date: 2022
Publisher: Springer
Part of: Parasitology Research
Volume: 121
Issue: 7
Start page: 2009
End page: 2017
Cutaneous leishmaniasis is a major global health issue, affecting more than 88 countries with 0.7-1.2 million new cases per year. T helper polarization plays a significant role in disease outcome, with Th1 responses being associated with resistance and Th2 responses being associated with susceptibility. IL-13 is an important Th2 cytokine with structural and functional similarities to IL-4. In this study, we demonstrate that administering exogenous IL-13 to Leishmania major-infected BALB/c mice increases parasite load in the infected paw and decreases tissue levels of the key Th1/Th2 cytokines IFN-γ and IL-4, respectively. Infecting BALB/c mice with a low dose of L. major has previously been shown to confer resistance to re-infection with a higher dose. In this study, we demonstrate that administration of exogenous IL-13 early in the course of the initial low-dose infection abrogates acquired resistance to high-dose re-infection, as measured by infected paw thickness.
ISSN: 09320113
DOI: 10.1007/s00436-022-07539-y
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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