Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5613
Title: SARS-CoV-2 involvement in central nervous system tissue damage
Authors: Haidar, Muhammad Ali
Shakkour, Zaynab
Reslan, Mohammad Amine
Al-Haj, Nadine
Chamoun, Perla
Habashy, Karl
Kaafarani, Hasan
Shahjouei, Shima
Farran, Sarah H
Shaito, Abdullah
Saba, Esber S
Badran, Bassam
Sabra, Mirna
Kobeissy, Firas
Bizri, Maya
Affiliations: Faculty of Health Sciences 
Faculty of Medicine 
Keywords: CNS infection
COVID-19
Autoantibodies
Coagulopathy
Encephalitis
Neuroinflammation
Renin-angiotensin system
Viral encephalopathy
Issue Date: 2022
Publisher: National Library of Medicine
Part of: Neural Regeneration Research
Volume: 17
Issue: 6
Start page: 1228
End page: 1239
Abstract: 
As the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to spread globally, it became evident that the SARS-CoV-2 virus infects multiple organs including the brain. Several clinical studies revealed that patients with COVID-19 infection experience an array of neurological signs ranging in severity from headaches to life-threatening strokes. Although the exact mechanism by which the SARS-CoV-2 virus directly impacts the brain is not fully understood, several theories have been suggested including direct and indirect pathways induced by the virus. One possible theory is the invasion of SARS-CoV-2 to the brain occurs either through the bloodstream or via the nerve endings which is considered to be the direct route. Such findings are based on studies reporting the presence of viral material in the cerebrospinal fluid and brain cells. Nevertheless, the indirect mechanisms, including blood-clotting abnormalities and prolonged activation of the immune system, can result in further tissue and organ damages seen during the course of the disease. This overview attempts to give a thorough insight into SARS-CoV-2 coronavirus neurological infection and highlights the possible mechanisms leading to the neurological manifestations observed in infected patients.
URI: https://scholarhub.balamand.edu.lb/handle/uob/5613
ISSN: 1673-5374
DOI: 10.4103/1673-5374.327323
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Medical Laboratory Sciences

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