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Title: Associations of Omega-3 fatty acids with brain morphology and volume in cognitively healthy older adults: A narrative review
Authors: Macaron, Tony
Giudici, Kelly Virecoulon
Bowman, Gene L
Sinclair, Alan
Stephan, Elie
Vellas, Bruno
de Souto Barreto, Philipe
Affiliations: Faculty of Medicine 
Keywords: Brain morphology
Brain volume
Brainmagneticresonanceimaging (MRI)
Docosahexaenoic acid (DHA)
Eicosapentaenoic acid (EPA)
Fatty acids
omega-3 (ω−3)
Issue Date: 2021
Part of: Ageing Research Reviews
Volume: 67
Human neurodevelopment is complete by the 4th decade of life at which point brain atrophy ensues with variable rate and regionality into old age. Literally all regions of the brain experience atrophy with older age, however the pattern and rate of atrophy can dictate the behavioral consequences (i.e., cognitive impairment, Alzheimer's disease). Substantial research has aimed to discover the reasons why some people experience greater morphologic changes that produce undesirable consequences with aging and how it may be prevented. One possible explanation is diet, particularly fish consumption and the intake of omega-3 polyunsaturated fatty acids (omega 3) concentrated in fish oil. This narrative review examines the available evidence on the association between omega-3 and brain volume in non-demented older adults.
ISSN: 15681637
DOI: 10.1016/j.arr.2021.101300
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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