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Title: Microbial transformation of cefotaxime and medrysone and the biological activity of their metabolites
Other Titles: Microbial transformation of cefotaxime & medrysone & the biological activity of their metabolites
Authors: Boujaoudé, Marie-Anne
Advisors: Abdel-Massih, Roula
Subjects: Biotransformation
Issue Date: 2015
Microbial transformation has been widely used in the past decades for the production of analogues of several bioactive compounds that are hardly synthesized by classical chemical routes. Cefotaxime, a drug to which many bacteria are gaining resistance, was fed to several fungi in the hope of obtaining a biotransformed product having a functional group that would bypass this resistance. Cefotaxime was not biotransformed by Cunninghamella blackesleenea, Rhizopus stolonifer, Aspergillus niger and Cunninghamella blackesleenea. Medrysone is a steroidal drug used to treat conjunctive inflammations. Microbial biotransformation of medrysone was investigated using Rhizopus stolonifer. Four metabolites were obtained; three were previously identified and the fourth is a newly synthesized compound. This new metabolite was not found to be cytotoxic thus the biological activity should be studied. This work led to the optimization of methods to biotransform antibiotics such as cefotaxime (choice of TLC plates and extraction) and to the discovery of new metabolites that can be potential drug candidates.
Includes bibliographical references (p.77-88).

Supervised by Dr. Roula Abdel Massih.
Rights: This object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holder
Ezproxy URL: Link to full text
Type: Thesis
Appears in Collections:UOB Theses and Projects

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