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dc.contributor.advisorAbdel-Massih, Roulaen_US
dc.contributor.authorBoujaoudé, Marie-Anneen_US
dc.descriptionIncludes bibliographical references (p.77-88).en_US
dc.descriptionSupervised by Dr. Roula Abdel Massih.en_US
dc.description.abstractMicrobial transformation has been widely used in the past decades for the production of analogues of several bioactive compounds that are hardly synthesized by classical chemical routes. Cefotaxime, a drug to which many bacteria are gaining resistance, was fed to several fungi in the hope of obtaining a biotransformed product having a functional group that would bypass this resistance. Cefotaxime was not biotransformed by Cunninghamella blackesleenea, Rhizopus stolonifer, Aspergillus niger and Cunninghamella blackesleenea. Medrysone is a steroidal drug used to treat conjunctive inflammations. Microbial biotransformation of medrysone was investigated using Rhizopus stolonifer. Four metabolites were obtained; three were previously identified and the fourth is a newly synthesized compound. This new metabolite was not found to be cytotoxic thus the biological activity should be studied. This work led to the optimization of methods to biotransform antibiotics such as cefotaxime (choice of TLC plates and extraction) and to the discovery of new metabolites that can be potential drug candidates.en_US
dc.description.statementofresponsibilityby Marie-Anne Boujaoudéen_US
dc.format.extentxii, 88 p. :ill., tables ;30 cmen_US
dc.rightsThis object is protected by copyright, and is made available here for research and educational purposes. Permission to reuse, publish, or reproduce the object beyond the personal and educational use exceptions must be obtained from the copyright holderen_US
dc.titleMicrobial transformation of cefotaxime and medrysone and the biological activity of their metabolitesen_US
dc.title.alternativeMicrobial transformation of cefotaxime & medrysone & the biological activity of their metabolitesen_US
dc.contributor.departmentDepartment of Biologyen_US
dc.contributor.facultyFaculty of Arts and Sciencesen_US
dc.contributor.institutionUniversity of Balamanden_US
dc.description.degreeMSc in Biologyen_US
Appears in Collections:UOB Theses and Projects
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