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|Title:||Preparation and Characterization of Antifungal Drug-Loaded Poly(Dl-Lactide-Co-Caprolactone) and Poly(L-Lactide-Co-Caprolactone-Co-Glycolide) Microspheres||Authors:||Kassab, Rima
|Affiliations:||Department of Chemistry
Department of Chemistry
|Issue Date:||2011||Part of:||International journal of novel drug delivery technology||Volume:||1||Issue:||4||Start page:||213||End page:||219||Abstract:||
Objective: To incorporate, an antifungal drug, nystatin, in two biodegradable polymers, Poly(DL-lactide-co-caprolactone) and poly(L-lactide-co-caprolactone-co-glycolide). Methods: Microspheres with different drug masses were prepared using solvent evaporation. They were evaluated for percentage yield, drug entrapment, particle size, morphology using Scanning Electron Microscopy, interaction study by Fourier Transform-Infrared Red spectroscopy, stability and in vitro release. Results:Microspheres of both polymers had a homogeneous size between 80 and 110 µm, and a spherical shape. Fourier Transform-Infrared showed no chemical interaction between the drug and the polymer. Results were not the same for drug entrapment; Poly(DL-lactide-co-caprolactone) microspheres showed a drug entrapment dependent on the quantity of nystatin used, while for poly(L-lactide-co-caprolactone-co-glycolide) microspheres, it was relatively small and close for all formulations. Conclusion: in vitro release study showed that nystatin release from both kinds of microspheres was slow during the first days, followed by an increase to reach a maximum of 90%.
|Appears in Collections:||Department of Chemistry|
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