Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2427
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dc.contributor.authorKassab, Rimaen_US
dc.contributor.authorYammine, Paoloen_US
dc.contributor.authorMoussa, Dimaen_US
dc.date.accessioned2020-12-23T09:13:06Z-
dc.date.available2020-12-23T09:13:06Z-
dc.date.issued2011-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2427-
dc.description.abstractObjective: To incorporate, an antifungal drug, nystatin, in two biodegradable polymers, Poly(DL-lactide-co-caprolactone) and poly(L-lactide-co-caprolactone-co-glycolide). Methods: Microspheres with different drug masses were prepared using solvent evaporation. They were evaluated for percentage yield, drug entrapment, particle size, morphology using Scanning Electron Microscopy, interaction study by Fourier Transform-Infrared Red spectroscopy, stability and in vitro release. Results:Microspheres of both polymers had a homogeneous size between 80 and 110 µm, and a spherical shape. Fourier Transform-Infrared showed no chemical interaction between the drug and the polymer. Results were not the same for drug entrapment; Poly(DL-lactide-co-caprolactone) microspheres showed a drug entrapment dependent on the quantity of nystatin used, while for poly(L-lactide-co-caprolactone-co-glycolide) microspheres, it was relatively small and close for all formulations. Conclusion: in vitro release study showed that nystatin release from both kinds of microspheres was slow during the first days, followed by an increase to reach a maximum of 90%.en_US
dc.format.extent7 p.en_US
dc.language.isoengen_US
dc.subjectMicrospheresen_US
dc.subjectPoly(DL-lactide-co-caprolactone)en_US
dc.subjectPoly(L-lactide-co-caprolactone-co-glycolide)en_US
dc.subjectNystatinen_US
dc.subjectIn vitroen_US
dc.titlePreparation and characterization of antifungal drug-loaded poly(Dl-Lactide-Co-Caprolactone) and poly(L-Lactide-Co-Caprolactone-Co-Glycolide) microspheresen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationDepartment of Chemistryen_US
dc.contributor.affiliationDepartment of Chemistryen_US
dc.description.volume1en_US
dc.description.issue4en_US
dc.description.startpage213en_US
dc.description.endpage219en_US
dc.date.catalogued2018-05-24-
dc.description.statusPublisheden_US
dc.identifier.OlibID180627-
dc.relation.ispartoftextInternational journal of novel drug delivery technologyen_US
dc.provenance.recordsourceOliben_US
crisitem.author.parentorgFaculty of Arts and Sciences-
Appears in Collections:Department of Chemistry
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