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Title: Left ventricular model using second-order electromechanical coupling: effects of viscoelastic damping
Authors: Karam, Elie 
Abche, Antoine 
Affiliations: Department of Electrical Engineering 
Department of Electrical Engineering 
Keywords: Myocardial sarcomere
Cardiac pump
Excitationcontraction coupling
Issue Date: 2006
Part of: International journal of biomedical and biological engineering
Volume: 1
Issue: 11
Start page: 168
End page: 173
It is known that the heart interacts with and adapts to its venous and arterial loading conditions. Various experimental studies and modeling approaches have been developed to investigate the underlying mechanisms. This paper presents a model of the left ventricle derived based on nonlinear stress-length myocardial characteristics integrated over truncated ellipsoidal geometry, and second-order dynamic mechanism for the excitation-contraction coupling system. The results of the model presented here describe the effects of the viscoelastic damping element of the electromechanical coupling system on the hemodynamic response. Different heart rates are considered to study the pacing effects on the performance of the left-ventricle against constant preload and afterload conditions under various damping conditions. The results indicate that the pacing process of the left ventricle has to take into account, among other things, the viscoelastic damping conditions of the myofilament excitation-contraction process.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Electrical Engineering

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