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Title: Immunomodulatory effect of natural and modified Citrus pectin on cytokine levels in the spleen of BALB/c mice
Authors: Merheb, Rihab Al
Abdel-Massih, Roula
Karam, Marc 
Affiliations: Department of Biology 
Department of Biology 
Keywords: Citrus pectin
Modified Citrus Pectin
Issue Date: 2019
Part of: International journal of biological macromolecules
Volume: 121
Start page: 1
End page: 5
Pectin is present in the cell wall of different vegetables and fruits. Beside its importance in the plant cell wall, pectin has enticed great attention for its beneficial effects on human health. It was shown to decrease cholesterol levels, to possess anti-oxidative, anti-bacterial and anti-cancer activity. The immunomodulatory activity of pectin and its mechanism of action is recently being investigated. In this study, the differential immunomodulatory activities of both CP (citrus pectin) and MCP (modified citrus pectin) were investigated. Females BALB/c mice (20–25 g) were randomly divided into 7 groups and different concentrations of CP and MCP (0%, 1.5%, 3% and 5%) were added to their drinking water for 21 days. Then, the splenic level of IL-1β, IL-4, IL-10, IL-17, IFN-γ and TNF-α were evaluated using ELISA. Both CP and MCP exhibited immunomodulatory activities by increasing the levels of the pro-inflammatory cytokines IL-17, IFN-γ and TNF-α levels. This tendency seems to be regulated by the up-regulation of IL-4 levels but with no major effect on those of IL-10. Therefore, CP and especially MCP have potential immunomodulatory effects which might be highly beneficial in immunotherapy.
DOI: 10.1016/j.ijbiomac.2018.09.189
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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