Please use this identifier to cite or link to this item:
Title: The combination of CRP isoforms with oxLDL decreases TNF-α and IL-6 release by U937‑derived macrophages
Authors: Krayem, Imtissal
Bazzi, Samer 
Karam, Marc 
Affiliations: Department of Biology 
Department of Biology 
Issue Date: 2017
Part of: Journal of biomedical reports
Volume: 7
Issue: 3
Start page: 272
End page: 276
C-reactive protein (CRP) and oxidized low density lipoprotein (oxLDL) serve major roles at both early and advanced stages of atherosclerosis. CRP exists in two isoforms, monomeric (m) and pentameric (p), that bring about pro‑ or anti‑inflammatory effects in macrophages. In addition, CRP may form a complex with oxidized low‑density lipoprotein (oxLDL) via phosphatidylcholine, thus decreasing its pro‑inflammatory effects within macrophages. The aim of the present study was to investigate the single and the combined effects of mCRP, pCRP and oxLDL on U937‑derived macrophages. In the current study, U937‑derived macrophages were treated in vitro with different combinations of CRP isoforms with or without oxLDL. The levels of major inflammatory cytokines [interleukin (IL)‑1β, IL‑6, IL‑8 and tumor necrosis factor (TNF)‑α] along with the production of reactive oxygen species (ROS) were determined. TNF‑α and IL‑6 levels were significantly decreased (P<0.05) by the effect of mCRP and pCRP combined with oxLDL. No significant changes were observed in IL‑1β, IL‑8 or ROS levels.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

Show full item record

Google ScholarTM


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.