Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/1658
Title: Atenolol Reduces Leishmania major-Induced Hyperalgesia and TNF-α Without Affecting IL-1β or Keratinocyte Derived Chemokines (KC)
Authors: Karam, Marc 
Merckbawi, Rana
Salman, Sara 
Mobasheri, Ali
Affiliations: Department of Biology 
Department of Biology 
Keywords: Atenolol
Leishmania major
NF-αlpha
Prostanoids
Sympathetic amines
Subjects: Inflammation
Hyperalgesia
Issue Date: 2016
Part of: Frontiers in pharmacology journal
Volume: 7
Issue: 22
Start page: 1
End page: 10
Abstract: 
Infection with a high dose of the intracellular parasitic protozoan Leishmania major induces a sustained hyperalgesia in susceptible BALB/c mice accompanied by up-regulation of the pro-inflammatory cytokines IL-1β and IL-6. Interleukin-13 (IL-13) has been shown to reduce this hyperalgesia (despite increased levels of IL-6) and the levels of IL-1β during and after the treatment period. These findings favor the cytokine cascade leading to the production of sympathetic amines (involving TNF-α and KC) over prostaglandins (involving IL-lβ and IL-6) as the final mediators of hyperalgesia. The aim of this study was to investigate the effect of daily treatment with the β-blockers atenolol on L. major-induced inflammation in mice with respect to hyperalgesia as well as the levels of TNF-α and KC (the analog of IL-8 in mice). Our data demonstrates that atenolol is able to reduce the L. major induced sustained peripheral hyperalgesia, which does not seem to involve a direct role for neither IL-lβ nor KC. Moreover, our results show that TNF-α may play a pivotal and direct role in sensitizing the peripheral nerve endings (nociceptors) since its level was reduced during the period of atenolol treatment, which correlates well with the reduction of the observed peripheral, but not central, hyperalgesia. These findings contribute to a better understanding of the cytokine cascade leading to hyperalgesia and may lead to the development of new and more efficient medications for many types of pain.
URI: https://scholarhub.balamand.edu.lb/handle/uob/1658
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

Show full item record

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.