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Title: Antimicrobial activity of polyphenols and alkaloids in middle eastern plants
Authors: Othman, Leen
Sleiman, Ahmad
Abdel-Massih, Roula
Affiliations: Department of Biology 
Issue Date: 2019
Part of: Frontiers in microbiology journal
Volume: 10
Issue: 911
Start page: 1
End page: 28
Antibiotic-resistant microorganisms have been an ever-growing concern over the past years. This has led researchers to direct their attention onto plants to be able to discover new possible antimicrobial compounds. The Middle East encompasses a wide spectrum of plant diversity with over 20,000 different species in habitats ranging from deserts to snow-capped mountains. Several plant secondary metabolites and their derivatives have been identified as possible antimicrobial agents. Among the secondary metabolites studied, alkaloids and polyphenols have shown strong antimicrobial activity. Polyphenols are one of the most numerous and diverse group of secondary metabolites; their antioxidant properties provide the basis for antimicrobial effects. Alkaloids provided the underlying structure for the development of several antibiotics with a diverse range of action. The ability of some plant secondary metabolites to act as resistance-modifying agents is a promising field in mitigating the spread of bacterial resistance.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Biology

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