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Title: Formulation of modified microspheres based on cyclodextrin-lactic acid polymers
Authors: Kassab, Rima 
Ghanem, Noha
Yammine, Paolo 
Fessi, Hatem
Parrot-Loppez, Hélen
Affiliations: Department of Chemistry 
Department of Chemistry 
Keywords: Poly L-lactic acid
Peptidic synthesis
Subjects: Amphotericin B
Issue Date: 2009
Conference: Lebanese Association for the Advancement of Science (LAAS) International Science Conference (16th : 13-15 Nov 2009 : Beirut Arab Universirty, Beirut, Lebanon) 
Polymers, based on Poly L-lactic acid (L-PLA) and coupled with β-Cyclodextrin (β-CD), have been used for the preparation of microspheres for drug encapsulation. The strategy was based on the modification of the terminal carboxylic group of L-PLA (73.000) by coupling it with a β-CD in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation was found to be 80%. Characterizations of the new product were carried out using 1 H NMR, gel permeation chromatography, and acid base titration. The size of the functionalized microspheres was determined to be 211 µm by Dynamic Light Scattering (DLS). Amphotericin B (AmB), a polyenic antifungal molecule, has been incorporated in L-PLA coupled with β-CD microspheres. The maximal quantity of AmB encapsulated, reported to 100 mg of the microspheres, was 7.2 mg (encapsulation ratio 60% by mol).
Type: Conference Presentation
Appears in Collections:Department of Chemistry

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