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dc.contributor.authorKassab, Rimaen_US
dc.contributor.authorGhanem, Nohaen_US
dc.contributor.authorYammine, Paoloen_US
dc.contributor.authorFessi, Hatemen_US
dc.contributor.authorParrot-Loppez, Hélenen_US
dc.description.abstractPolymers, based on Poly L-lactic acid (L-PLA) and coupled with β-Cyclodextrin (β-CD), have been used for the preparation of microspheres for drug encapsulation. The strategy was based on the modification of the terminal carboxylic group of L-PLA (73.000) by coupling it with a β-CD in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation was found to be 80%. Characterizations of the new product were carried out using 1 H NMR, gel permeation chromatography, and acid base titration. The size of the functionalized microspheres was determined to be 211 µm by Dynamic Light Scattering (DLS). Amphotericin B (AmB), a polyenic antifungal molecule, has been incorporated in L-PLA coupled with β-CD microspheres. The maximal quantity of AmB encapsulated, reported to 100 mg of the microspheres, was 7.2 mg (encapsulation ratio 60% by mol).en_US
dc.subjectPoly L-lactic aciden_US
dc.subjectPeptidic synthesisen_US
dc.subject.lcshAmphotericin Ben_US
dc.titleFormulation of modified microspheres based on cyclodextrin-lactic acid polymersen_US
dc.typeConference Presentationen_US
dc.relation.conferenceLebanese Association for the Advancement of Science (LAAS) International Science Conference (16th : 13-15 Nov 2009 : Beirut Arab Universirty, Beirut, Lebanon)en_US
dc.contributor.affiliationDepartment of Chemistryen_US
dc.contributor.affiliationDepartment of Chemistryen_US
dc.provenance.recordsourceOliben_US of Arts and Sciences- of Arts and Sciences-
Appears in Collections:Department of Chemistry
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