Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7328
Title: Mortality risk in patients with obesity and COVID-19 infection: a systematic review and meta-analysis
Authors: Haber, Rachelle
Ghezzawi, Malak
Puzantian, Houry
Haber, Marc
Saad, Sacha
Ghandour, Yara
El Bachour, Joseph
Yazbeck, Anthony
Hassanieh, Ghinwa
Mehdi, Celine
Ismail, Dima
Abi-Kharma, Elias
El-Zein, Ola
Khamis, Assem
Chakhtoura, Marlene
Mantzoros, Christos
Affiliations: Faculty of Medicine 
Keywords: COVID-19
Mortality
Obesity
Issue Date: 2024-02-13
Publisher: Elsevier
Part of: Metabolism: Clinical and Experimental
Volume: 155
Abstract: 
Obesity is a risk factor for severe respiratory diseases, including COVID-19 infection. Meta-analyses on mortality risk were inconsistent. We systematically searched 3 databases (Medline, Embase, CINAHL) and assessed the quality of studies using the Newcastle-Ottawa tool (CRD42020220140). We included 199 studies from US and Europe, with a mean age of participants 41.8-78.2 years, and a variable prevalence of metabolic co-morbidities of 20-80 %. Exceptionally, one third of the studies had a low prevalence of obesity of <20 %. Compared to patients with normal weight, those with obesity had a 34 % relative increase in the odds of mortality (p-value 0.002), with a dose-dependent relationship. Subgroup analyses showed an interaction with the country income. There was a high heterogeneity in the results, explained by clinical and methodologic variability across studies. We identified one trial only comparing mortality rate in vaccinated compared to unvaccinated patients with obesity; there was a trend for a lower mortality in the former group. Mortality risk in COVID-19 infection increases in parallel to an increase in BMI. BMI should be included in the predictive models and stratification scores used when considering mortality as an outcome in patients with COVID-19 infections. Furthermore, patients with obesity might need to be prioritized for COVID-19 vaccination.
URI: https://scholarhub.balamand.edu.lb/handle/uob/7328
ISSN: 00260495
DOI: 10.1016/j.metabol.2024.155812
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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