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Title: Satiety: a gut-brain-relationship
Authors: Barakat, Ghinwa M
Ramadan, Wiam
Assi, Ghaith
Khoury, Noura El 
Affiliations: Department of Psychology 
Keywords: GLP-1
Issue Date: 2024-02-17
Publisher: National Library of Medicine
Part of: The journal of physiological sciences : JPS
Volume: 74
Issue: 1
Start page: 1
End page: 11
Many hormones act on the hypothalamus to control hunger and satiety through various pathways closely associated with several factors. When food is present in the gastro intestinal (GI) tract, enteroendocrine cells (EECs) emit satiety signals such as cholecystokinin (CCK), glucagon like peptide-1 (GLP-1) and peptide YY (PYY), which can then communicate with the vagus nerve to control food intake. More specifically, satiety has been shown to be particularly affected by the GLP-1 hormone and its receptor agonists that have lately been acknowledged as a promising way to reduce weight. In addition, there is increasing evidence that normal flora is also involved in the peripheral, central, and reward system that impact satiety. Moreover, neurologic pathways control satiety through neurotransmitters. In this review, we discuss the different roles of each of the GLP-1 hormone and its agonist, gut microbiomes, as well as neurotransmitters and their interconnected relation in the regulation of body's satiety homeostasis.
DOI: 10.1186/s12576-024-00904-9
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Psychology

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