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Title: Loss of CEACAM1 in hepatocytes causes hepatic fibrosis
Authors: Zaidi, Sobia
Asalla, Suman
Muturi, Harrison T
Russo, Lucia
Abdolahipour, Raziyeh
Belew, Getachew Debas
Iglesias, Maria Benitez
Feraudo, Mary
Leon, Lensay
Kuo, Enoch
Liu, Xiuli
Kumarasamy, Sivarajan
Ghadieh, Hilda 
Gatto-Weis, Cara
Zarrinpar, Ali
Duarte, Sergio
Najjar, Sonia M
Affiliations: Faculty of Medicine 
Keywords: Fibrosis stage
Hepatic stellate cells
Insulin extraction
Insulin resistance
Issue Date: 2024-02-21
Part of: European Journal of Clinical Investigation
The role of insulin resistance in hepatic fibrosis in Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes insulin clearance to maintain insulin sensitivity and repress de novo lipogenesis, as bolstered by the development of insulin resistance and steatohepatitis in AlbuminCre + Cc1fl/fl mice with liver-specific mouse gene encoding CEACAM1 protein (Ceacam1) deletion. We herein investigated whether these mice also developed hepatic fibrosis and whether hepatic CEACAM1 is reduced in patients with MASH at different fibrosis stages.
ISSN: 00142972
DOI: 10.1111/eci.14177
Type: Journal Article
Appears in Collections:Faculty of Medicine

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