Please use this identifier to cite or link to this item:
https://scholarhub.balamand.edu.lb/handle/uob/7271
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Zaidi, Sobia | en_US |
dc.contributor.author | Asalla, Suman | en_US |
dc.contributor.author | Muturi, Harrison T | en_US |
dc.contributor.author | Russo, Lucia | en_US |
dc.contributor.author | Abdolahipour, Raziyeh | en_US |
dc.contributor.author | Belew, Getachew Debas | en_US |
dc.contributor.author | Iglesias, Maria Benitez | en_US |
dc.contributor.author | Feraudo, Mary | en_US |
dc.contributor.author | Leon, Lensay | en_US |
dc.contributor.author | Kuo, Enoch | en_US |
dc.contributor.author | Liu, Xiuli | en_US |
dc.contributor.author | Kumarasamy, Sivarajan | en_US |
dc.contributor.author | Ghadieh, Hilda | en_US |
dc.contributor.author | Gatto-Weis, Cara | en_US |
dc.contributor.author | Zarrinpar, Ali | en_US |
dc.contributor.author | Duarte, Sergio | en_US |
dc.contributor.author | Najjar, Sonia M | en_US |
dc.date.accessioned | 2024-03-11T08:16:17Z | - |
dc.date.available | 2024-03-11T08:16:17Z | - |
dc.date.issued | 2024-02-21 | - |
dc.identifier.issn | 00142972 | - |
dc.identifier.uri | https://scholarhub.balamand.edu.lb/handle/uob/7271 | - |
dc.description.abstract | The role of insulin resistance in hepatic fibrosis in Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes insulin clearance to maintain insulin sensitivity and repress de novo lipogenesis, as bolstered by the development of insulin resistance and steatohepatitis in AlbuminCre + Cc1fl/fl mice with liver-specific mouse gene encoding CEACAM1 protein (Ceacam1) deletion. We herein investigated whether these mice also developed hepatic fibrosis and whether hepatic CEACAM1 is reduced in patients with MASH at different fibrosis stages. | en_US |
dc.language.iso | eng | en_US |
dc.subject | Fibrosis stage | en_US |
dc.subject | Hepatic stellate cells | en_US |
dc.subject | Insulin extraction | en_US |
dc.subject | Insulin resistance | en_US |
dc.subject | Steatohepatitis | en_US |
dc.title | Loss of CEACAM1 in hepatocytes causes hepatic fibrosis | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.1111/eci.14177 | - |
dc.identifier.pmid | 38381498 | - |
dc.identifier.scopus | 2-s2.0-85185926085 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85185926085 | - |
dc.contributor.affiliation | Faculty of Medicine | en_US |
dc.date.catalogued | 2024-03-11 | - |
dc.description.status | In Press | en_US |
dc.relation.ispartoftext | European Journal of Clinical Investigation | en_US |
Appears in Collections: | Faculty of Medicine |
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