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Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/7271
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dc.contributor.authorZaidi, Sobiaen_US
dc.contributor.authorAsalla, Sumanen_US
dc.contributor.authorMuturi, Harrison Ten_US
dc.contributor.authorRusso, Luciaen_US
dc.contributor.authorAbdolahipour, Raziyehen_US
dc.contributor.authorBelew, Getachew Debasen_US
dc.contributor.authorIglesias, Maria Benitezen_US
dc.contributor.authorFeraudo, Maryen_US
dc.contributor.authorLeon, Lensayen_US
dc.contributor.authorKuo, Enochen_US
dc.contributor.authorLiu, Xiulien_US
dc.contributor.authorKumarasamy, Sivarajanen_US
dc.contributor.authorGhadieh, Hildaen_US
dc.contributor.authorGatto-Weis, Caraen_US
dc.contributor.authorZarrinpar, Alien_US
dc.contributor.authorDuarte, Sergioen_US
dc.contributor.authorNajjar, Sonia Men_US
dc.date.accessioned2024-03-11T08:16:17Z-
dc.date.available2024-03-11T08:16:17Z-
dc.date.issued2024-02-21-
dc.identifier.issn00142972-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/7271-
dc.description.abstractThe role of insulin resistance in hepatic fibrosis in Metabolic dysfunction-Associated SteatoHepatitis (MASH) remains unclear. Carcinoembryonic Antigen-related Cell Adhesion Molecule1 protein (CEACAM1) promotes insulin clearance to maintain insulin sensitivity and repress de novo lipogenesis, as bolstered by the development of insulin resistance and steatohepatitis in AlbuminCre + Cc1fl/fl mice with liver-specific mouse gene encoding CEACAM1 protein (Ceacam1) deletion. We herein investigated whether these mice also developed hepatic fibrosis and whether hepatic CEACAM1 is reduced in patients with MASH at different fibrosis stages.en_US
dc.language.isoengen_US
dc.subjectFibrosis stageen_US
dc.subjectHepatic stellate cellsen_US
dc.subjectInsulin extractionen_US
dc.subjectInsulin resistanceen_US
dc.subjectSteatohepatitisen_US
dc.titleLoss of CEACAM1 in hepatocytes causes hepatic fibrosisen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.1111/eci.14177-
dc.identifier.pmid38381498-
dc.identifier.scopus2-s2.0-85185926085-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85185926085-
dc.contributor.affiliationFaculty of Medicineen_US
dc.date.catalogued2024-03-11-
dc.description.statusIn Pressen_US
dc.relation.ispartoftextEuropean Journal of Clinical Investigationen_US
Appears in Collections:Faculty of Medicine
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