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Title: Curcumin Polymer Based Nanospheres: Encapsulation and In Vitro Release
Authors: Yammine, Paolo 
Saliba, Cherine
Kassab, Rima 
Affiliations: Department of Chemistry 
Department of Chemistry 
Keywords: Poly(DL-lactide-co-glycolide)
Solvent evaporation
Issue Date: 2020
Part of: journal of chemistry and chemical sciences
Volume: 10
Issue: 1
Start page: 1
End page: 9
Curcumin is a yellow pigmented polyphenol, having multiple medicinal uses due to its anti-inflammatory, antioxidant and antimicrobial effects. The most important effect is its potential use in chemothearpy for cancer treatment. In this study curcumin is encapsulated in Poly(DL-lactide-co-glycolide) nanospheres using solvent evaporation technique by means of Tween 80 and Span 80 as surfactants. Drug encapsulation, drug loading, particle size, morphology, FT-IR analysis and in-vitro studies, were conducted to characterize the formulated nanospheres.The spherical nanoshperes showed a size ranging between 60 and 130 nm, having a maximum drug encapsulation of 24%. The lack of interaction between both drug and polymer during the nanosphere formulation was proven during the FT-IR study. The in-vitro studies showed a fast drug release.
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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