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|Title:||Curcumin Polymer Based Nanospheres: Encapsulation and In Vitro Release||Authors:||Yammine, Paolo
|Affiliations:||Department of Chemistry
Department of Chemistry
|Issue Date:||2020||Part of:||journal of chemistry and chemical sciences||Volume:||10||Issue:||1||Start page:||1||End page:||9||Abstract:||
Curcumin is a yellow pigmented polyphenol, having multiple medicinal uses due to its anti-inflammatory, antioxidant and antimicrobial effects. The most important effect is its potential use in chemothearpy for cancer treatment. In this study curcumin is encapsulated in Poly(DL-lactide-co-glycolide) nanospheres using solvent evaporation technique by means of Tween 80 and Span 80 as surfactants. Drug encapsulation, drug loading, particle size, morphology, FT-IR analysis and in-vitro studies, were conducted to characterize the formulated nanospheres.The spherical nanoshperes showed a size ranging between 60 and 130 nm, having a maximum drug encapsulation of 24%. The lack of interaction between both drug and polymer during the nanosphere formulation was proven during the FT-IR study. The in-vitro studies showed a fast drug release.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/7104||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Chemistry|
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