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Title: Biological applications of imiquimod analogues: An update (Review)
Authors: Obeid, Joelle
Shaito, Abdullah
Hajj, Hiba El
Deleuze-Masquefa, Carine
Bonnet, Pierre Antoine
El-Sabban, Marwan
Saliba, Jessica 
Affiliations: Department of Public Health 
Keywords: Cancer
Imiquimod analogues
Parasitic infections
Preclinical data
Issue Date: 2023-06-30
Publisher: SPANDIDOS Publications
Part of: World Academy of Sciences Journal
Volume: 5
Issue: 3
The last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of clinical trials, with only a handful being translated from the bench to bedside. One such example is imiquimod, an immune response modi‑ fier belonging to the imidazoquinoline family. Imiquimod was first approved by the US Food and Drug Administration for the topical treatment of anal and genital warts and actinic keratosis, and later exhibited a potent antitumor activity. This promising activity inspired the development of several imid‑ azoquinoxaline analogues and derivatives. The present review provides a comprehensive overview of the scientific literature on the chemical synthesis of imiquimod and several of its analogues, namely EAPB0203, EAPB0503 and EABP02303. The present review also discusses their preclinical proper‑ ties and mechanisms of action in the context of cancer and parasitic infections, highlighting the worthiness of translating these activities into therapeutic drugs.
ISSN: 26322900
DOI: 10.3892/wasj.2023.197
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Public Health

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