Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/6933
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dc.contributor.authorObeid, Joelleen_US
dc.contributor.authorShaito, Abdullahen_US
dc.contributor.authorHajj, Hiba Elen_US
dc.contributor.authorDeleuze-Masquefa, Carineen_US
dc.contributor.authorBonnet, Pierre Antoineen_US
dc.contributor.authorEl-Sabban, Marwanen_US
dc.contributor.authorSaliba, Jessicaen_US
dc.date.accessioned2023-08-09T07:04:27Z-
dc.date.available2023-08-09T07:04:27Z-
dc.date.issued2023-06-30-
dc.identifier.issn26322900-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/6933-
dc.description.abstractThe last decade witnessed intensive efforts in drug discovery and the emergence of thousands of molecules with potential for use as therapeutic targets. However, only a few hundred of these molecules reached the stage of clinical trials, with only a handful being translated from the bench to bedside. One such example is imiquimod, an immune response modi‑ fier belonging to the imidazoquinoline family. Imiquimod was first approved by the US Food and Drug Administration for the topical treatment of anal and genital warts and actinic keratosis, and later exhibited a potent antitumor activity. This promising activity inspired the development of several imid‑ azoquinoxaline analogues and derivatives. The present review provides a comprehensive overview of the scientific literature on the chemical synthesis of imiquimod and several of its analogues, namely EAPB0203, EAPB0503 and EABP02303. The present review also discusses their preclinical proper‑ ties and mechanisms of action in the context of cancer and parasitic infections, highlighting the worthiness of translating these activities into therapeutic drugs.en_US
dc.language.isoengen_US
dc.publisherSPANDIDOS Publicationsen_US
dc.subjectCanceren_US
dc.subjectImidazoquinoxalinesen_US
dc.subjectImiquimod analoguesen_US
dc.subjectImmunomodulationen_US
dc.subjectParasitic infectionsen_US
dc.subjectPreclinical dataen_US
dc.titleBiological applications of imiquimod analogues: An update (Review)en_US
dc.typeJournal Articleen_US
dc.identifier.doi10.3892/wasj.2023.197-
dc.identifier.scopus2-s2.0-85164812194-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85164812194-
dc.contributor.affiliationDepartment of Public Healthen_US
dc.description.volume5en_US
dc.description.issue3en_US
dc.date.catalogued2023-08-09-
dc.description.statusPublisheden_US
dc.identifier.openURLhttps://www.spandidos-publications.com/10.3892/wasj.2023.197en_US
dc.relation.ispartoftextWorld Academy of Sciences Journalen_US
crisitem.author.parentorgFaculty of Health Sciences-
Appears in Collections:Department of Public Health
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