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Title: Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer
Authors: El-Harakeh, Mohammad
Saliba, Jessica 
Sharaf Aldeen, Kawthar
Haidar, May
El Hajjar, Layal
Awad, Mireille Kallassy
Hashash, Jana G
Shirinian, Margret
El-Sabban, Marwan
Affiliations: Faculty of Health Sciences 
Department of Public Health 
Keywords: Colorectal cancer
Inflammation-induced carcinogenesis
Ulcerative colitis
Issue Date: 2022-10-28
Publisher: National Library of Medicine
Part of: World journal of gastroenterology
Volume: 28
Issue: 40
Start page: 5845
End page: 5864
Inflammatory bowel disease (IBD) constitutes a substantial risk factor for colorectal cancer. Connexin 43 (Cx43) is a protein that forms gap junction (GJ) complexes involved in intercellular communication, and its expression is altered under pathological conditions, such as IBD and cancer. Recent studies have implicated epigenetic processes modulating DNA methylation in the pathogenesis of diverse inflammatory and malignant diseases. The ten-eleven translocation-2 (TET-2) enzyme catalyzes the demethylation, hence, regulating the activity of various cancer-promoting and tumor-suppressor genes.
DOI: 10.3748/wjg.v28.i40.5845
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Public Health

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