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|Title:||Expression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal cancer||Authors:||El-Harakeh, Mohammad
Sharaf Aldeen, Kawthar
El Hajjar, Layal
Awad, Mireille Kallassy
Hashash, Jana G
|Affiliations:||Faculty of Health Sciences
Department of Public Health
|Issue Date:||2022||Publisher:||National Library of Medicine||Part of:||World journal of gastroenterology||Volume:||28||Issue:||40||Start page:||5845||End page:||5864||Abstract:||
Inflammatory bowel disease (IBD) constitutes a substantial risk factor for colorectal cancer. Connexin 43 (Cx43) is a protein that forms gap junction (GJ) complexes involved in intercellular communication, and its expression is altered under pathological conditions, such as IBD and cancer. Recent studies have implicated epigenetic processes modulating DNA methylation in the pathogenesis of diverse inflammatory and malignant diseases. The ten-eleven translocation-2 (TET-2) enzyme catalyzes the demethylation, hence, regulating the activity of various cancer-promoting and tumor-suppressor genes.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/6329||DOI:||10.3748/wjg.v28.i40.5845||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Public Health|
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