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Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/6329
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dc.contributor.authorEl-Harakeh, Mohammaden_US
dc.contributor.authorSaliba, Jessicaen_US
dc.contributor.authorSharaf Aldeen, Kawtharen_US
dc.contributor.authorHaidar, Mayen_US
dc.contributor.authorEl Hajjar, Layalen_US
dc.contributor.authorAwad, Mireille Kallassyen_US
dc.contributor.authorHashash, Jana Gen_US
dc.contributor.authorShirinian, Margreten_US
dc.contributor.authorEl-Sabban, Marwanen_US
dc.date.accessioned2022-11-24T07:38:26Z-
dc.date.available2022-11-24T07:38:26Z-
dc.date.issued2022-10-28-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/6329-
dc.description.abstractInflammatory bowel disease (IBD) constitutes a substantial risk factor for colorectal cancer. Connexin 43 (Cx43) is a protein that forms gap junction (GJ) complexes involved in intercellular communication, and its expression is altered under pathological conditions, such as IBD and cancer. Recent studies have implicated epigenetic processes modulating DNA methylation in the pathogenesis of diverse inflammatory and malignant diseases. The ten-eleven translocation-2 (TET-2) enzyme catalyzes the demethylation, hence, regulating the activity of various cancer-promoting and tumor-suppressor genes.en_US
dc.language.isoengen_US
dc.publisherNational Library of Medicineen_US
dc.subjectColorectal canceren_US
dc.subjectConnexinsen_US
dc.subjectDemethylationen_US
dc.subjectInflammation-induced carcinogenesisen_US
dc.subjectUlcerative colitisen_US
dc.titleExpression of the methylcytosine dioxygenase ten-eleven translocation-2 and connexin 43 in inflammatory bowel disease and colorectal canceren_US
dc.typeJournal Articleen_US
dc.identifier.doi10.3748/wjg.v28.i40.5845-
dc.identifier.pmid36353202-
dc.identifier.scopus2-s2.0-85141504173-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85141504173-
dc.contributor.affiliationFaculty of Health Sciencesen_US
dc.contributor.affiliationDepartment of Public Healthen_US
dc.description.volume28en_US
dc.description.issue40en_US
dc.description.startpage5845en_US
dc.description.endpage5864en_US
dc.date.catalogued2022-11-24-
dc.description.statusPublisheden_US
dc.identifier.openURLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9639657/en_US
dc.relation.ispartoftextWorld journal of gastroenterologyen_US
crisitem.author.parentorgFaculty of Health Sciences-
Appears in Collections:Department of Public Health
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