Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/6135
Title: Saffron Extract Attenuates Anxiogenic Effect and Improves Cognitive Behavior in an Adult Zebrafish Model of Traumatic Brain Injury
Authors: Chaoul, Victoria
Awad, Maria
Harb, Frederic 
Najjar, Fadia
Hamade, Aline
Nabout, Rita
Soueid, Jihane
Affiliations: Faculty of Medicine 
Keywords: Anxiolytic
Fear disinhibition
Memory performance
Saffron
Traumatic brain injury
Zebrafish
Issue Date: 2022-10-01
Publisher: MDPI
Part of: International Journal of Molecular Sciences
Volume: 23
Issue: 19
Abstract: 
Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood-brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. Saffron (Crocus sativus L.) is known for its anti-inflammatory and neuroprotective effects, which makes it a potential candidate for TBI treatment. Zebrafish (Danio rerio) shares a high degree of genetic homology and cell signaling pathways with mammals. Its active neuro-regenerative function makes it an excellent model organism for TBI therapeutic drug identification. The objective of this study was to assess the effect of saffron administration to a TBI zebrafish model by investigating behavioral outcomes such as anxiety, fear and memory skills using a series of behavioral tests. Saffron exhibited anxiolytic effect on anxiety-like behaviors, and showed prevention of fear inhibition observed after TBI. It improved learning and enhanced memory performance. These results suggest that saffron could be a novel therapeutic enhancer for neural repair and regeneration of networks post-TBI.
URI: https://scholarhub.balamand.edu.lb/handle/uob/6135
ISSN: 16616596
DOI: 10.3390/ijms231911600
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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