Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/6135
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dc.contributor.authorChaoul, Victoriaen_US
dc.contributor.authorAwad, Mariaen_US
dc.contributor.authorHarb, Fredericen_US
dc.contributor.authorNajjar, Fadiaen_US
dc.contributor.authorHamade, Alineen_US
dc.contributor.authorNabout, Ritaen_US
dc.contributor.authorSoueid, Jihaneen_US
dc.date.accessioned2022-10-24T06:46:56Z-
dc.date.available2022-10-24T06:46:56Z-
dc.date.issued2022-10-01-
dc.identifier.issn16616596-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/6135-
dc.description.abstractTraumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood-brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. Saffron (Crocus sativus L.) is known for its anti-inflammatory and neuroprotective effects, which makes it a potential candidate for TBI treatment. Zebrafish (Danio rerio) shares a high degree of genetic homology and cell signaling pathways with mammals. Its active neuro-regenerative function makes it an excellent model organism for TBI therapeutic drug identification. The objective of this study was to assess the effect of saffron administration to a TBI zebrafish model by investigating behavioral outcomes such as anxiety, fear and memory skills using a series of behavioral tests. Saffron exhibited anxiolytic effect on anxiety-like behaviors, and showed prevention of fear inhibition observed after TBI. It improved learning and enhanced memory performance. These results suggest that saffron could be a novel therapeutic enhancer for neural repair and regeneration of networks post-TBI.en_US
dc.language.isoengen_US
dc.publisherMDPIen_US
dc.subjectAnxiolyticen_US
dc.subjectFear disinhibitionen_US
dc.subjectMemory performanceen_US
dc.subjectSaffronen_US
dc.subjectTraumatic brain injuryen_US
dc.subjectZebrafishen_US
dc.titleSaffron Extract Attenuates Anxiogenic Effect and Improves Cognitive Behavior in an Adult Zebrafish Model of Traumatic Brain Injuryen_US
dc.typeJournal Articleen_US
dc.identifier.doi10.3390/ijms231911600-
dc.identifier.pmid36232902-
dc.identifier.scopus2-s2.0-85139916679-
dc.identifier.urlhttps://api.elsevier.com/content/abstract/scopus_id/85139916679-
dc.contributor.affiliationFaculty of Medicineen_US
dc.description.volume23en_US
dc.description.issue19en_US
dc.date.catalogued2022-10-24-
dc.description.statusPublisheden_US
dc.identifier.openURLhttps://www.mdpi.com/1422-0067/23/19/11600/htmen_US
dc.relation.ispartoftextInternational Journal of Molecular Sciencesen_US
dc.description.campusFOM main campusen_US
Appears in Collections:Faculty of Medicine
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