Please use this identifier to cite or link to this item:
https://scholarhub.balamand.edu.lb/handle/uob/6135
DC Field | Value | Language |
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dc.contributor.author | Chaoul, Victoria | en_US |
dc.contributor.author | Awad, Maria | en_US |
dc.contributor.author | Harb, Frederic | en_US |
dc.contributor.author | Najjar, Fadia | en_US |
dc.contributor.author | Hamade, Aline | en_US |
dc.contributor.author | Nabout, Rita | en_US |
dc.contributor.author | Soueid, Jihane | en_US |
dc.date.accessioned | 2022-10-24T06:46:56Z | - |
dc.date.available | 2022-10-24T06:46:56Z | - |
dc.date.issued | 2022-10-01 | - |
dc.identifier.issn | 16616596 | - |
dc.identifier.uri | https://scholarhub.balamand.edu.lb/handle/uob/6135 | - |
dc.description.abstract | Traumatic brain injury (TBI) has the highest mortality rates worldwide, yet effective treatment remains unavailable. TBI causes inflammatory responses, endoplasmic reticulum stress, disruption of the blood-brain barrier and neurodegeneration that lead to loss of cognition, memory and motor skills. Saffron (Crocus sativus L.) is known for its anti-inflammatory and neuroprotective effects, which makes it a potential candidate for TBI treatment. Zebrafish (Danio rerio) shares a high degree of genetic homology and cell signaling pathways with mammals. Its active neuro-regenerative function makes it an excellent model organism for TBI therapeutic drug identification. The objective of this study was to assess the effect of saffron administration to a TBI zebrafish model by investigating behavioral outcomes such as anxiety, fear and memory skills using a series of behavioral tests. Saffron exhibited anxiolytic effect on anxiety-like behaviors, and showed prevention of fear inhibition observed after TBI. It improved learning and enhanced memory performance. These results suggest that saffron could be a novel therapeutic enhancer for neural repair and regeneration of networks post-TBI. | en_US |
dc.language.iso | eng | en_US |
dc.publisher | MDPI | en_US |
dc.subject | Anxiolytic | en_US |
dc.subject | Fear disinhibition | en_US |
dc.subject | Memory performance | en_US |
dc.subject | Saffron | en_US |
dc.subject | Traumatic brain injury | en_US |
dc.subject | Zebrafish | en_US |
dc.title | Saffron Extract Attenuates Anxiogenic Effect and Improves Cognitive Behavior in an Adult Zebrafish Model of Traumatic Brain Injury | en_US |
dc.type | Journal Article | en_US |
dc.identifier.doi | 10.3390/ijms231911600 | - |
dc.identifier.pmid | 36232902 | - |
dc.identifier.scopus | 2-s2.0-85139916679 | - |
dc.identifier.url | https://api.elsevier.com/content/abstract/scopus_id/85139916679 | - |
dc.contributor.affiliation | Faculty of Medicine | en_US |
dc.description.volume | 23 | en_US |
dc.description.issue | 19 | en_US |
dc.date.catalogued | 2022-10-24 | - |
dc.description.status | Published | en_US |
dc.identifier.openURL | https://www.mdpi.com/1422-0067/23/19/11600/htm | en_US |
dc.relation.ispartoftext | International Journal of Molecular Sciences | en_US |
dc.description.campus | FOM main campus | en_US |
Appears in Collections: | Faculty of Medicine |
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