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Title: | SARS-CoV-2, COVID-19, and Reproduction: Effects on Fertility, Pregnancy, and Neonatal Life | Authors: | Harb, Julien Debs, Nour Rima, Mohamad Wu, Yingliang Cao, Zhijian Kovacic, Hervé Fajloun, Ziad Sabatier, Jean-Marc |
Affiliations: | Faculty of Medicine | Keywords: | ACE2 COVID-19 RAS SARS-CoV-2 Fertility Neonatal life Reproduction |
Issue Date: | 2022-01-22 | Publisher: | National Library of Medicine | Part of: | Biomedicines | Volume: | 10 | Issue: | 8 | Abstract: | Since its discovery in Wuhan, China, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread over the world, having a huge impact on people's lives and health. The respiratory system is often targeted in people with the coronavirus disease 2019 (COVID-19). The virus can also infect many organs and tissues in the body, including the reproductive system. The consequences of the SARS-CoV-2 infection on fertility and pregnancy in hosts are poorly documented. Available data on other coronaviruses, such as severe acute respiratory syndrome (SARS-CoV) and Middle Eastern Respiratory Syndrome (MERS-CoV) coronaviruses, identified pregnant women as a vulnerable group with increased pregnancy-related complications. COVID-19 was also shown to impact pregnancy, which can be seen in either the mother or the fetus. Pregnant women more likely require COVID-19 intensive care treatment than non-pregnant women, and they are susceptible to giving birth prematurely and having their newborns admitted to the neonatal intensive care unit. Angiotensin converting enzyme 2 (ACE2), a key player of the ubiquitous renin-angiotensin system (RAS), is the principal host cellular receptor for SARS-CoV-2 spike protein. ACE2 is involved in the regulation of both male and female reproductive systems, suggesting that SARS-CoV-2 infection and associated RAS dysfunction could affect reproduction. Herein, we review the current knowledge about COVID-19 consequences on male and female fertility, pregnant women, and their fetuses. Furthermore, we describe the effects of COVID-19 vaccination on reproduction. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/6072 | ISSN: | 2227-9059 | DOI: | 10.3390/biomedicines10081775 | Open URL: | Link to full text | Type: | Journal Article |
Appears in Collections: | Faculty of Medicine |
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