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Title: Evolution of Cyclodextrin Nanosponges
Authors: Caldera, Fabrizio
Tannous, Maria
Cavalli, Roberta
Zanetti, Marco
Trotta, Francesco
Affiliations: Faculty of Arts and Sciences 
Keywords: Cyclodextrin nanosponges
Functionalized nanosponges
Molecularly imprinted polymers
Stimuli responsive polymers
Issue Date: 2017-01-15
Publisher: Elsevier
Part of: International Journal of Pharmaceutics
Volume: 53
Issue: 2
Start page: 470
End page: 479
Cyclodextrin-based nanosponges (CD-NSs) are insoluble, highly cross-linked 3D network polymers used in several scientific and technological fields, the main area of investigation concerns the pharmaceutical applications, in which CD-NSs have been mostly employed as drug delivery systems. CD-NSs can be generally grouped into four consecutive generations, taking into account their chemical composition and properties. The 1st generation of NSs are plain nanosponges, subdivided into four main types: urethane, carbonate, ester and ether NSs, depending on the chemical nature of the functional group connecting the CD to the cross-linker. The 2nd generation of NSs are modified nanosponges characterized by specific properties, such as fluorescence and electric charge. The 3rd generation of NSs is represented by stimuli-responsive CD polymers, which are able to modulate their behavior according to external variations in the environment, such as pH and temperature gradients, oxidative/reducing conditions, and finally the 4th generation of NSs, a new family of molecularly imprinted CD polymers (MIPs), exhibiting a high selectivity towards specific molecules. The following review focuses on the evolution of cyclodextrin nanosponges, listing some examples of each generation.
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2017.06.072
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Chemistry

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