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Title: Frontiers of Ferroptosis in Cancer Treatment
Authors: Durr-e-shahwar Malik
Mirna Azalea Romero
Saiyada Fatima Maida Halim
Deena Elsori
Youssef, Lara 
Yulaevna, Ishmuratova Margarita
Sabitaliyevich, Uteuliyev Yerzhan
Attar, Rukset
Affiliations: Faculty of Medicine 
Keywords: Cancer
Cell signaling
Issue Date: 2022
Publisher: National Library of Medicine
Part of: Cellular and Molecular Biology
Volume: 68
Issue: 2
Start page: 213
End page: 226
Recent phenomenal advancements in the genomic and proteomic technologies and rapid breakthroughs in the interpretation of large gene expression datasets have enabled scientists to comprehensively characterize the gene signatures involved in ferroptosis. Ferroptosis is an iron-dependent form of non-apoptotic cell death that has gained worthwhile attention of both basic and clinical researchers. Ferroptosis has dichotomous, context-dependent functions both as a tumor suppressor and promoter of carcinogenesis. Essentially, pharmacological modulation of ferroptosis by its induction as well as its inhibition holds enormous potential to overcome drug-resistance and to improve the therapeutic potential of chemotherapeutic drugs in wide variety of cancers.
Date received: 15th March, 2022
Date accepted: 10th June, 2022
We have witnessed incredible and ever-growing interest among clinical and basic researchers in characterization of regulators of the ferroptosis in cancer and in reaping the full benefits of this wealth of information to improve cancer prevention and treatment. Ferroptosis has a highly context-dependent and complex role in carcinogenesis and metastasis. Design and development of translational anticancer agents is challenging and relies on continuing research for a better understanding of the regulatory mechanisms and signaling pathways which mechanistically modulate ferroptosis.
DOI: 10.14715/cmb/2022.68.2.31
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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