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dc.contributor.authorDurr-e-shahwar Maliken_US
dc.contributor.authorMirna Azalea Romeroen_US
dc.contributor.authorSaiyada Fatima Maida Halimen_US
dc.contributor.authorDeena Elsorien_US
dc.contributor.authorYoussef, Laraen_US
dc.contributor.authorYulaevna, Ishmuratova Margaritaen_US
dc.contributor.authorSabitaliyevich, Uteuliyev Yerzhanen_US
dc.contributor.authorAttar, Rukseten_US
dc.descriptionDate received: 15th March, 2022 Date accepted: 10th June, 2022 We have witnessed incredible and ever-growing interest among clinical and basic researchers in characterization of regulators of the ferroptosis in cancer and in reaping the full benefits of this wealth of information to improve cancer prevention and treatment. Ferroptosis has a highly context-dependent and complex role in carcinogenesis and metastasis. Design and development of translational anticancer agents is challenging and relies on continuing research for a better understanding of the regulatory mechanisms and signaling pathways which mechanistically modulate ferroptosis.en_US
dc.description.abstractRecent phenomenal advancements in the genomic and proteomic technologies and rapid breakthroughs in the interpretation of large gene expression datasets have enabled scientists to comprehensively characterize the gene signatures involved in ferroptosis. Ferroptosis is an iron-dependent form of non-apoptotic cell death that has gained worthwhile attention of both basic and clinical researchers. Ferroptosis has dichotomous, context-dependent functions both as a tumor suppressor and promoter of carcinogenesis. Essentially, pharmacological modulation of ferroptosis by its induction as well as its inhibition holds enormous potential to overcome drug-resistance and to improve the therapeutic potential of chemotherapeutic drugs in wide variety of cancers.en_US
dc.publisherNational Library of Medicineen_US
dc.subjectCell signalingen_US
dc.titleFrontiers of Ferroptosis in Cancer Treatmenten_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.relation.ispartoftextCellular and Molecular Biologyen_US
dc.description.campusFOM main campusen_US
Appears in Collections:Faculty of Medicine
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