Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/5632
Title: Analysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: A cross-sectional study in a middle eastern population
Authors: Ghosn, Youssef
Kamareddine, Mohammed Hussein
Tawk, Antonios
Bou-Ayash, Naseem
Bou-Ayash, Haneen
Mokamer, Nader
Yared, Rawad
Aoun, Mouna
Khoury, Salem
Cortas, George
Jabbour, Gide
Bedran, Khalil
Farhat, Said
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Faculty of Medicine 
Faculty of Medicine 
Keywords: Celiac disease
Correa's cascade
Duodenal adenocarcinoma
Gastritis
H. pylori
Issue Date: 2019-01-01
Publisher: National Library of Medicine
Part of: BMJ Open Gastroenterology
Volume: 6
Issue: 1
Abstract: 
Objective Correa's cascade is a â € Model for Gastric Cancer Development' described by Peleyo Correa. The reversibility of Correa's cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which Helicobacter pylori is detected, treated, and the effect on prognosis. Herein, we aim to determine the prevalence of various precancerous and cancerous gastric lesions in patients presenting with dyspepsia, the prevalence of gastritis and H. pylori infection, the prevalence of duodenal pathology in patients presenting with dyspepsia, identify the stage of H. pylori detection in relation to Correa's cascade, and investigate a possible relationship between H. pylori and celiac disease. Design Retrospective cross-sectional study conducted on a middle eastern population at a Lebanese tertiary hospital centre. 1428 patients presenting with dyspepsia underwent gastroscopy with gastric and duodenal biopsies. Variables include age, sex, presence/absence of H. pylori infection, and histopathological analysis of gastric and duodenal biopsies. Results Being above 40 years of age was associated with increased likelihood of exhibiting abnormal gastric biopsy result. Gastritis and metaplasia were detected more frequently than glandular atrophy (p<0.001) with gastritis being present the most (p<0.001). The presence of H. pylori and the gastric biopsy results were not associated with any of the duodenal biopsy results. Conclusion The burden of H. pylori infection in patients with dyspepsia was high. H. pylori was detected at various precancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found.
URI: https://scholarhub.balamand.edu.lb/handle/uob/5632
DOI: 10.1136/bmjgast-2019-000330
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

Show full item record

Record view(s)

7
checked on Aug 14, 2022

Google ScholarTM

Check

Dimensions Altmetric

Dimensions Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.