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dc.contributor.authorGhosn, Youssefen_US
dc.contributor.authorKamareddine, Mohammed Husseinen_US
dc.contributor.authorTawk, Antoniosen_US
dc.contributor.authorBou-Ayash, Naseemen_US
dc.contributor.authorBou-Ayash, Haneenen_US
dc.contributor.authorMokamer, Naderen_US
dc.contributor.authorYared, Rawaden_US
dc.contributor.authorAoun, Mounaen_US
dc.contributor.authorKhoury, Salemen_US
dc.contributor.authorCortas, Georgeen_US
dc.contributor.authorJabbour, Gideen_US
dc.contributor.authorBedran, Khalilen_US
dc.contributor.authorFarhat, Saiden_US
dc.description.abstractObjective Correa's cascade is a â € Model for Gastric Cancer Development' described by Peleyo Correa. The reversibility of Correa's cascade remains debatable. The literature contains insufficient data on the specific stage of the cascade during which Helicobacter pylori is detected, treated, and the effect on prognosis. Herein, we aim to determine the prevalence of various precancerous and cancerous gastric lesions in patients presenting with dyspepsia, the prevalence of gastritis and H. pylori infection, the prevalence of duodenal pathology in patients presenting with dyspepsia, identify the stage of H. pylori detection in relation to Correa's cascade, and investigate a possible relationship between H. pylori and celiac disease. Design Retrospective cross-sectional study conducted on a middle eastern population at a Lebanese tertiary hospital centre. 1428 patients presenting with dyspepsia underwent gastroscopy with gastric and duodenal biopsies. Variables include age, sex, presence/absence of H. pylori infection, and histopathological analysis of gastric and duodenal biopsies. Results Being above 40 years of age was associated with increased likelihood of exhibiting abnormal gastric biopsy result. Gastritis and metaplasia were detected more frequently than glandular atrophy (p<0.001) with gastritis being present the most (p<0.001). The presence of H. pylori and the gastric biopsy results were not associated with any of the duodenal biopsy results. Conclusion The burden of H. pylori infection in patients with dyspepsia was high. H. pylori was detected at various precancerous lesions with varying significance. The prevalence of duodenal adenocarcinoma in dyspeptic patients is unexpectedly high. No association between gastric and duodenal pathologies was found.en_US
dc.publisherNational Library of Medicineen_US
dc.subjectCeliac diseaseen_US
dc.subjectCorrea's cascadeen_US
dc.subjectDuodenal adenocarcinomaen_US
dc.subjectH. pylorien_US
dc.titleAnalysis of gastric and duodenal biopsy results in patients presenting with dyspepsia: A cross-sectional study in a middle eastern populationen_US
dc.typeJournal Articleen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.contributor.affiliationFaculty of Medicineen_US
dc.relation.ispartoftextBMJ Open Gastroenterologyen_US
dc.description.campusSGH campusen_US
Appears in Collections:Faculty of Medicine
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