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Title: Detection and genomic characterization of mcr-9 in Enterobacter hormaechei recovered from a pediatric patient in Lebanon
Authors: Ragheed Khodor
Tamara Salloum
Tamima El Jisr
Chaar, Mira El 
Sima Tokajian
Affiliations: Faculty of Health Sciences 
Keywords: Colistin
Enterobacter hormaechei
Issue Date: 2021
Publisher: Elsevier
Part of: Infection Genetic Evolution
Volume: 94
Background: The emergence and spread of mobilized colistin resistance (mcr) genes are a global health concern.

Objectives: In this study, we report the detection and genomic characterization of mcr-9 in a colistin-susceptible Enterobacter hormaechei (EH23) recovered from a pediatric patient in Lebanon.

Results: EH23 was susceptible to colistin with a minimal inhibitory concentration (MIC) of 0.25 mg/L. Studying the mcr-9 genetic environment revealed that it was chromosomal and was bracketed by IS903 and IS26. QseCB, a two-component regulatory system, mediating the inducible expression of mcr-9 gene was not detected within the mcr-9 cassette but elsewhere on the genome. EH23 was 99.96% similar based on average nucleotide identity (ANI) to another mcr-negative E. hormaechei OIPH-N069 isolate recovered from Japan. wgSNP-based phylogenetic analysis divided all mcr-9 positive E. hormaechei isolates into five clades (I to V), with isolates from the same ST being clustered together.

Conclusion: The silent spread of mcr-9, particularly in the globally successful ST-78 Enterobacter lineage, is worrisome and requires close monitoring in humans and animals
DOI: 10.1016/j.meegid.2021.105014.
Ezproxy URL: Link to full text
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Department of Medical Laboratory Sciences

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