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|Title:||Detection and genomic characterization of mcr-9 in Enterobacter hormaechei recovered from a pediatric patient in Lebanon||Authors:||Ragheed Khodor
Tamima El Jisr
Chaar, Mira El
|Affiliations:||Faculty of Health Sciences||Keywords:||Colistin
|Issue Date:||2021||Publisher:||Elsevier||Part of:||Infection Genetic Evolution||Volume:||94||Abstract:||
Background: The emergence and spread of mobilized colistin resistance (mcr) genes are a global health concern.
Objectives: In this study, we report the detection and genomic characterization of mcr-9 in a colistin-susceptible Enterobacter hormaechei (EH23) recovered from a pediatric patient in Lebanon.
Results: EH23 was susceptible to colistin with a minimal inhibitory concentration (MIC) of 0.25 mg/L. Studying the mcr-9 genetic environment revealed that it was chromosomal and was bracketed by IS903 and IS26. QseCB, a two-component regulatory system, mediating the inducible expression of mcr-9 gene was not detected within the mcr-9 cassette but elsewhere on the genome. EH23 was 99.96% similar based on average nucleotide identity (ANI) to another mcr-negative E. hormaechei OIPH-N069 isolate recovered from Japan. wgSNP-based phylogenetic analysis divided all mcr-9 positive E. hormaechei isolates into five clades (I to V), with isolates from the same ST being clustered together.
Conclusion: The silent spread of mcr-9, particularly in the globally successful ST-78 Enterobacter lineage, is worrisome and requires close monitoring in humans and animals
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/5144||DOI:||10.1016/j.meegid.2021.105014.||Ezproxy URL:||Link to full text||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Medical Laboratory Sciences|
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