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Title: | Detection and genomic characterization of mcr-9 in Enterobacter hormaechei recovered from a pediatric patient in Lebanon | Authors: | Ragheed Khodor Tamara Salloum Tamima El Jisr Chaar, Mira El Sima Tokajian |
Affiliations: | Faculty of Health Sciences | Keywords: | Colistin Enterobacter hormaechei mcr-9 qseB qseC |
Issue Date: | 2021 | Publisher: | Elsevier | Part of: | Infection Genetic Evolution | Volume: | 94 | Abstract: | Background: The emergence and spread of mobilized colistin resistance (mcr) genes are a global health concern. Objectives: In this study, we report the detection and genomic characterization of mcr-9 in a colistin-susceptible Enterobacter hormaechei (EH23) recovered from a pediatric patient in Lebanon. Results: EH23 was susceptible to colistin with a minimal inhibitory concentration (MIC) of 0.25 mg/L. Studying the mcr-9 genetic environment revealed that it was chromosomal and was bracketed by IS903 and IS26. QseCB, a two-component regulatory system, mediating the inducible expression of mcr-9 gene was not detected within the mcr-9 cassette but elsewhere on the genome. EH23 was 99.96% similar based on average nucleotide identity (ANI) to another mcr-negative E. hormaechei OIPH-N069 isolate recovered from Japan. wgSNP-based phylogenetic analysis divided all mcr-9 positive E. hormaechei isolates into five clades (I to V), with isolates from the same ST being clustered together. Conclusion: The silent spread of mcr-9, particularly in the globally successful ST-78 Enterobacter lineage, is worrisome and requires close monitoring in humans and animals |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/5144 | DOI: | 10.1016/j.meegid.2021.105014. | Ezproxy URL: | Link to full text | Open URL: | Link to full text | Type: | Journal Article |
Appears in Collections: | Department of Medical Laboratory Sciences |
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