Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2498
Title: Results from the Survey of Antibiotic Resistance (SOAR) 2011-13 in the Gulf States
Authors: Jamsheer, A.
Rafay, A. M.
Torumkuney, D.
Daoud, Ziad
Morrissey, I.
Affiliations: Faculty of Medicine 
Keywords: Amoxicillin
Ampicillin
Ceftriaxone
Erythromycin
Azithromycin
Streptococcus pyogenes
Antibiotic resistance
Bacterial
Penicillin
cefepime
cefuroxime
Ciprofloxacin
Clarithromycin
Diffusion
Haemophilus influenzae
amoxicillin-potassium clavulanate combination
Bahrain
cefaclor
cefixime
Oman
Streptococcus pneumoniae
United Arab Emirates
macrolides
levofloxacin
pharmacodynamics
moxifloxacin
Antimicrobial agents
Antimicrobial susceptibility
cefpodoxime
surveillance, medical
multi-antibiotic resistance
malnutrition-inflammation-cachexia syndrome
Subjects: Antibiotics
Community
Lebanon
Issue Date: 2016
Part of: Journal of antimicrobial chemotherapy
Volume: 71
Issue: 1
Start page: i45
End page: i61
Abstract: 
Objectives To provide surveillance data on the susceptibility of community-acquired respiratory tract isolates from four Gulf and Near East countries from 2011 to 2013. Methods MICs were determined using Etests® for all antibiotics evaluated except erythromycin, where testing was by disc diffusion. Susceptibility was assessed using CLSI, EUCAST and pharmacokinetic/pharmacodynamic (PK/PD) breakpoints. Results Seven hundred and twenty-six respiratory isolates comprising 265 isolates of Streptococcus pneumoniae, 125 isolates of Streptococcus pyogenes and 336 isolates of Haemophilus influenzae were collected from Bahrain, Lebanon, Oman and the United Arab Emirates (UAE). Among S. pneumoniae, susceptibility to penicillin was low in the UAE and Bahrain. Macrolide susceptibility was ∼45%–60% in the UAE and Oman but higher in Lebanon (73.7%) and Bahrain (84%–85%). Penicillin susceptibility using CLSI intravenous breakpoints was >85% in all countries. Antibiotic susceptibility of S. pneumoniae was lower in UAE and Oman. Among S. pyogenes isolates, resistance to erythromycin was highest in Oman (31.6%) but <20% in the other countries. In H. influenzae, susceptibility to most antibiotics was high, except for ampicillin in Lebanon (70.2%) and amoxicillin in Oman (95.4%). Lebanon also had a high percentage (14.9%) of β-lactamase-positive isolates with non-susceptibility to ampicillin. Amoxicillin/clavulanic acid susceptibility was >95% in all countries. Use of EUCAST versus CLSI breakpoints demonstrated profound differences for cefaclor and cefuroxime in S. pneumoniae and H. influenzae, with EUCAST showing lower susceptibility. Conclusions There was considerable variability in susceptibility among countries in the same region. Thus, continued surveillance is necessary to track future changes in antibiotic resistance.
URI: https://scholarhub.balamand.edu.lb/handle/uob/2498
Open URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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