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|Title:||Poly (DL-Lactide-co-caprolactone) as drug carrier for antifungal agent amphotericin B||Authors:||Yammine, Paolo
Moussa, Rima Fawzi
|Affiliations:||Department of Chemistry
Department of Chemistry
|Subjects:||Drug delivery systems
|Issue Date:||2012||Part of:||International journal of drug delivery||Volume:||4||Issue:||4||Start page:||477||End page:||483||Abstract:||
The objective of the present study is the preparation and characterization of Amphotericin B-loaded poly(DL-lactide-co-caprolactone) microspheres. The microspheres were prepared based on o/w emulsion solvent evaporation technique by varying the quantity of drug introduced. Characterization experiments included drug encapsulation efficiency, drug loading, particle size, morphology, FT-IR, stability, and drug release study. The drug encapsulation and drug loading increased with increasing drug mass. The microspheres exhibited homogeneous particle sizes with a spherical shape and porous surface. FT-IR spectrum of drug-loaded microspheres confirmed the absence of polymer-drug interaction. The stability study showed no major difference in the degradation of microspheres after 3 months of storage. Finally, the in vitro drug release behavior of the prepared formulations revealed a sustained release profile, with a burst effect for the formulations with the highest drug loadings.
|URI:||https://scholarhub.balamand.edu.lb/handle/uob/2408||Open URL:||Link to full text||Type:||Journal Article|
|Appears in Collections:||Department of Chemistry|
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