Please use this identifier to cite or link to this item: https://scholarhub.balamand.edu.lb/handle/uob/2408
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dc.contributor.authorYammine, Paoloen_US
dc.contributor.authorKassab, Rimaen_US
dc.contributor.authorMoussa, Dimaen_US
dc.contributor.authorMoussa, Rima Fawzien_US
dc.date.accessioned2020-12-23T09:12:38Z-
dc.date.available2020-12-23T09:12:38Z-
dc.date.issued2012-
dc.identifier.urihttps://scholarhub.balamand.edu.lb/handle/uob/2408-
dc.description.abstractThe objective of the present study is the preparation and characterization of Amphotericin B-loaded poly(DL-lactide-co-caprolactone) microspheres. The microspheres were prepared based on o/w emulsion solvent evaporation technique by varying the quantity of drug introduced. Characterization experiments included drug encapsulation efficiency, drug loading, particle size, morphology, FT-IR, stability, and drug release study. The drug encapsulation and drug loading increased with increasing drug mass. The microspheres exhibited homogeneous particle sizes with a spherical shape and porous surface. FT-IR spectrum of drug-loaded microspheres confirmed the absence of polymer-drug interaction. The stability study showed no major difference in the degradation of microspheres after 3 months of storage. Finally, the in vitro drug release behavior of the prepared formulations revealed a sustained release profile, with a burst effect for the formulations with the highest drug loadings.en_US
dc.format.extent6 p.en_US
dc.language.isoengen_US
dc.subjectPoly(DL-lactide-co-caprolactone)en_US
dc.subjectMicrospheresen_US
dc.subject.lcshDrug delivery systemsen_US
dc.subject.lcshAmphotericin Ben_US
dc.titlePoly (DL-Lactide-co-caprolactone) as drug carrier for antifungal agent amphotericin Ben_US
dc.typeJournal Articleen_US
dc.contributor.affiliationDepartment of Chemistryen_US
dc.contributor.affiliationDepartment of Chemistryen_US
dc.description.volume4en_US
dc.description.issue4en_US
dc.description.startpage477en_US
dc.description.endpage483en_US
dc.date.catalogued2017-10-30-
dc.description.statusPublisheden_US
dc.identifier.OlibID174594-
dc.identifier.openURLhttp://www.arjournals.org/index.php/ijdd/article/view/832en_US
dc.relation.ispartoftextInternational journal of drug deliveryen_US
dc.provenance.recordsourceOliben_US
crisitem.author.parentorgFaculty of Arts and Sciences-
Appears in Collections:Department of Chemistry
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