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Title: Mitochondrial uncoupling proteins-What is their physiological role?
Authors: Echtay, Karim 
Affiliations: Faculty of Medicine 
Keywords: Proton leak
Reactive oxygen species
Lipid peroxidation
Insulin secretion
Mild uncoupling
Uncoupling protein
Subjects: Mitochondria
Issue Date: 2007
Part of: Journal of free radical biology and medicine
Volume: 43
Issue: 10
Start page: 1351
End page: 1371
The physiological functions of the mitochondrial uncoupling proteins (UCP2 and UCP3) are still under debate. There is, however, ample evidence to indicate that, in contrast to UCP1, they are not crucial for nonshivering thermogenesis and do not catalyze the basal proton conductance of mitochondria. Rather, there is good evidence that they increase mitochondrial proton conductance when activated by superoxide, reactive oxygen species derivatives such as hydroxynonenal, and other alkenals or their analogues. This review critically examines the evidence of the different proposed mechanisms for UCPs functions, namely (a) to export fatty acid anions from mitochondria, (b) to regulate insulin secretion in pancreatic β-cells, and (c) to cause mild uncoupling and so diminish mitochondrial superoxide production, hence protecting against oxidative damage. Beside, available scientific data on UCP4 and UCP5/BMCP1 will be reviewed. However, their physiological function has not yet been established.
DOI: 10.1016/j.freeradbiomed.2007.08.011
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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