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Title: Hydroxynonenal and uncoupling proteins : a model for protection against oxidative damage
Authors: Echtay, Karim 
Pakay, Julian L.
Esteves, Telma C.
Brand, Martin D
Affiliations: Faculty of Medicine 
Keywords: Proton leak
Lipid peroxidation
Retinoic acid
Subjects: Mitochondria
Issue Date: 2005
Part of: Journal of biofactors
Volume: 24
Issue: 1-4
Start page: 119
End page: 130
In this mini review we summarize recent studies from our laboratory that show the involvement of superoxide and the lipid peroxidation product 4-hydroxynonenal in the regulation of mitochondrial uncoupling. Superoxide produced during mitochondrial respiration is a major cause of the cellular oxidative damage that may underlie degenerative diseases and ageing. Superoxide production is very sensitive to the magnitude of the mitochondrial protonmotive force, so can be strongly decreased by mild uncoupling. Superoxide is able to give rise to other reactive oxygen species, which elicit deleterious effects primarily by oxidizing intracellular components, including lipids, DNA and proteins. Superoxide-induced lipid peroxidation leads to the production of reactive aldehydes, including 4-hydroxynonenal. These aldehydic lipid peroxidation products are in turn able to modify proteins such as mitochondrial uncoupling proteins and the adenine nucleotide translocase, converting them into active proton transporters. This activation induces mild uncoupling and so diminishes mitochondrial superoxide production, hence protecting against disease and oxidative damage at the expense of energy production.
DOI: 10.1002/biof.5520240114
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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