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Title: HPLC separaton of hydrophobic atropisomers
Authors: Allouch, Ahmad
Hassan, Inas EL
Zeine, Abdel Razzak El
Abou Dalle, Adib
Bouchkara, Mohammad
Nakat, Hanna El 
Omar, Fawaz El
Affiliations: Department of Chemistry 
Keywords: 2-aryl-imino-N-(2-aryl)-thiazoline
Atropisomeric separation
Issue Date: 2012
Part of: International journal of chemical sciences
Volume: 10
Issue: 2
Start page: 799
End page: 807
The separation of racemic-N-[(2Z)-4-methyl-3-(2-methylphenyl)-1,3-thiazol-2(3H)-ylidene]-N- (2-chloro-4-nitrophenyl)amine, which belongs to the 2-aryl-imino-N-(2-aryl)-thiazoline family, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-propan-2-ol as a mobile phase. The effects of mobile phase composition, concentration of HP-γ-CD and time of incubation of the CD-substrate on separation were systematically investigated to establish the optimum resolution conditions.
Type: Journal Article
Appears in Collections:Department of Chemistry

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