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https://scholarhub.balamand.edu.lb/handle/uob/2077| Title: | HPLC separaton of hydrophobic atropisomers | Authors: | Allouch, Ahmad Hassan, Inas EL Zeine, Abdel Razzak El Abou Dalle, Adib Bouchkara, Mohammad Nakat, Hanna El Omar, Fawaz El |
Affiliations: | Department of Chemistry | Keywords: | 2-aryl-imino-N-(2-aryl)-thiazoline HP−γ-CD HPLC Atropisomeric separation |
Issue Date: | 2012 | Part of: | International journal of chemical sciences | Volume: | 10 | Issue: | 2 | Start page: | 799 | End page: | 807 | Abstract: | The separation of racemic-N-[(2Z)-4-methyl-3-(2-methylphenyl)-1,3-thiazol-2(3H)-ylidene]-N- (2-chloro-4-nitrophenyl)amine, which belongs to the 2-aryl-imino-N-(2-aryl)-thiazoline family, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-propan-2-ol as a mobile phase. The effects of mobile phase composition, concentration of HP-γ-CD and time of incubation of the CD-substrate on separation were systematically investigated to establish the optimum resolution conditions. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/2077 | Type: | Journal Article |
| Appears in Collections: | Department of Chemistry |
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