UOBScholar Hub
UOB Libraries created the UOBScholar Hub, an Institutional Repository (IR) for archiving and collecting all the research output of the UOB community. It aims to improve the visibility, usage and impact of research conducted at UOB. Materials included are: academic journal articles, conference papers and presentations, books and book chapters, ongoing research papers, reports and patents.
Submit your Publication
Please use this identifier to cite or link to this item:
https://scholarhub.balamand.edu.lb/handle/uob/2077| Title: | HPLC separaton of hydrophobic atropisomers | Authors: | Allouch, Ahmad Hassan, Inas EL Zeine, Abdel Razzak El Abou Dalle, Adib Bouchkara, Mohammad Nakat, Hanna El Omar, Fawaz El |
Affiliations: | Department of Chemistry | Keywords: | 2-aryl-imino-N-(2-aryl)-thiazoline HP−γ-CD HPLC Atropisomeric separation |
Issue Date: | 2012 | Part of: | International journal of chemical sciences | Volume: | 10 | Issue: | 2 | Start page: | 799 | End page: | 807 | Abstract: | The separation of racemic-N-[(2Z)-4-methyl-3-(2-methylphenyl)-1,3-thiazol-2(3H)-ylidene]-N- (2-chloro-4-nitrophenyl)amine, which belongs to the 2-aryl-imino-N-(2-aryl)-thiazoline family, to collect its atropisomers, was studied using reversed-phase high-performance liquid chromatography (RP-HPLC) with hydroxypropyl-gamma-cyclodextrin (HP-γ-CD) as a complexing additive to the racemic mixture (to obtain chiral molecules) and hexane-propan-2-ol as a mobile phase. The effects of mobile phase composition, concentration of HP-γ-CD and time of incubation of the CD-substrate on separation were systematically investigated to establish the optimum resolution conditions. |
URI: | https://scholarhub.balamand.edu.lb/handle/uob/2077 | Type: | Journal Article |
| Appears in Collections: | Department of Chemistry |
Show full item record
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.