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Title: Effect of muramyl peptides on mitochondrial respiration
Authors: Jamal, N. El
Bahr, George M. 
Echtay, Karim 
Affiliations: Faculty of Medicine 
Faculty of Medicine 
Issue Date: 2009
Part of: Clinical & experimental immunology
Volume: 155
Start page: 72
End page: 78
Muramyl peptides have been shown to exert several biological activities including potentiation of humoral and cell-mediated immunity and stimulation of natural resistance. The mode of action of muramyl peptides has not been elucidated fully and the immunological activities of some derivatives have been associated with toxic effects, including pyrogenicity and inflammatory reactions. Nevertheless, the impact of muramyl peptides on mitochondrial respiration has never been addressed. In this study, the in vitro effects of muramyl peptides on rat liver mitochondria were examined. Toxic muramyl peptides induced a significant decrease in respiratory control ratio versus non-toxic analogues. These results were confirmed by in vivo studies in mice and were extended to mitochondria isolated from spleens. Our data address, for the first time, the effect of muramyl peptides on mitochondrial bioenergetics. Further studies are required to reveal the mechanism of mitochondrial toxicity in relation to the damaging effects of toxic muramyl peptides.
DOI: 10.1111/j.1365-2249.2008.03794.x
Ezproxy URL: Link to full text
Type: Journal Article
Appears in Collections:Faculty of Medicine

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